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dc.contributor.authorWassano, Natália Sayuri
dc.contributor.authorLeite, Ariely Barbosa [UNIFESP]
dc.contributor.authorReichert-Lima, Franqueline
dc.contributor.authorSchreiber, Angelica Zaninelli
dc.contributor.authorMoretti, Nilmar S. [UNIFESP]
dc.contributor.authorDamasio, André
dc.date.accessioned2021-11-26T21:42:52Z
dc.date.available2021-11-26T21:42:52Z
dc.date.issued2020
dc.identifier.urihttps://repositorio.unifesp.br/xmlui/handle/11600/62315
dc.description.abstractIn recent years, the intensification of the use of immunosuppressive therapies has increased the incidence of invasive infections caused by opportunistic fungi. Considering that, the spread of azole resistance and amphotericin B (AmB) inefficiency against some clinical and environmental isolates has been described. Thus, to avoid a global problem when controlling fungal infections and critical failures in medicine, and food security, new approaches for drug target identification and for the development of new treatments that are more effective against pathogenic fungi are desired. Recent studies indicate that protein acetylation is present in hundreds of proteins of different cellular compartments and is involved in several biological processes, i.e., metabolism, translation, gene expression regulation, and oxidative stress response, from prokaryotes and eukaryotes, including fungi, dem- onstrating that lysine acetylation plays an important role in essential mechanisms. Lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), the two enzyme families responsible for regulating protein acetylation levels, have been explored as drug targets for the treatment of several human diseases and infections. Aspergilli have on average 8 KAT genes and 11 KDAC genes in their genomes. This review aims to summarize the available knowledge about Aspergillus spp. azole resistance mechanisms and the role of lysine acetylation in the control of biological processes in fungi. We also want to discuss the lysine acetylation as a potential target for fungal infection treatment and drug target discovery.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.languageengpt_BR
dc.publisherSBMpt_BR
dc.relation.ispartofBrazilian Journal of Microbiologypt_BR
dc.rightsAcesso abertopt_BR
dc.subjectDrug resistancept_BR
dc.subjectLysine acetylationpt_BR
dc.subjectKATspt_BR
dc.subjectKDACspt_BR
dc.subjectAspergillus spp.pt_BR
dc.titleLysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp.pt_BR
dc.typeArtigopt_BR
dc.description.sponsorshipIDFAPESP: 2018/09948-0pt_BR
dc.description.sponsorshipIDCNPq: 424729/2018pt_BR
dc.identifier.doihttps://doi.org/10.1007/s42770-020-00253-wpt_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.graduateProgramMicrobiologia e Imunologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
dc.contributor.authorLatteshttp://lattes.cnpq.br/2131472726202687pt_BR
unifesp.departamentoMicrobiologia, Imunologia e Parasitologiapt_BR


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