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- ItemThermal modification and oxidation of cassava starch to produce biodegradable films(David F. Bahr, 2023-01-11) Oliveira, Isabella de Lima [UNIFESP]; Falcão, Lucas de Souza [UNIFESP]; Campelo, Pedro Henrique; Moraes, Mariana Agostini de [UNIFESP]; http://lattes.cnpq.br/0644374691728856Biopolymers appear as a great candidate for plastic substitution in a wide array of industries, attracting interest for its nontoxicity and biodegradability. Among the biopolymers, starch can be highlighted due to its abundance and capability to undergo diverse chemical and physical modifications. Therefore, the aim of this work is to produce films with native and modified cassava starch and analyze its physicochemical properties. Starch was extracted directly from cassava; it was modified by thermal treatment and oxidation and the films were produced by casting. The films presented smooth and homogeneous surfaces. The thermal treatment induced the most significant changes on film characteristics, increasing the elongation at break and the swelling capability. Therefore, the thermal modification of cassava starch resulted in films with enhanced properties, which may find applications from packaging to biomedical devices.
- ItemStarch as a matrix for incorporation and release of bioactive compounds: fundamentals and applications(Alexander Boker, 2022-06-10) Falcão, Lucas de Souza [UNIFESP]; Coelho, Deborah Bento [UNIFESP]; Veggi, Priscilla Carvalho [UNIFESP]; Campelo, Pedro Henrique; Albuquerque, Patrícia; Moraes, Mariana Agostini de [UNIFESP]; http://lattes.cnpq.br/0644374691728856Due to its abundance in nature and low cost, starch is one of the most relevant raw materials for replacing synthetic polymers in a number of applications. It is generally regarded as non-toxic, biocompatible, and biodegradable and, therefore, a safe option for biomedical, food, and packaging applications. In this review, we focused on studies that report the use of starch as a matrix for stabilization, incorporation, or release of bioactive compounds, and explore a wide range of applications of starch-based materials. One of the key application areas for bioactive compounds incorporated in starch matrices is the pharmaceutical industry, especially in orally disintegrating films. The packaging industry has also shown great interest in using starch films, especially those with antioxidant activity. Regarding food technology, starch can be used as a stabilizer in nanoemulsions, thus allowing the incorporation of bioactive compounds in a variety of food types. Starch also presents potential in the cosmetic industry as a delivery system. However, there are still several types of industry that could benefit from the incorporation of starch matrices with bioactive compounds, which are described in this review. In addition, the use of microbial bioactive compounds in starch matrices represents an almost unexplored field still to be investigated.
- ItemOptimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi(Elsevier, 2022) Varela, Marina T. [UNIFESP]; Amaral, Maiara; Romanelli, Maiara M.; Levatti, Erica V. de Castro; Tempone, Andre G.; Fernandes, João Paulo dos Santos [UNIFESP]; http://lattes.cnpq.br/7259164526317967Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without efficient treatment for chronic patients. Despite the efforts, no new drugs have been approved for this disease in the last 60 years. Molecular modifications based on a natural product led to the development of a series of compounds (LINS03 series) with promising antitrypanosomal activity, however previous chemometric analysis revealed a significant impact of excessive lipophilicity and low aqueous solubility on potency of amine and amide derivatives. Therefore, this work reports different modifications in the core structure to achieve adequate balance of the physicochemical properties along with biological activity. A set of 34 analogues were designed considering predicted properties related to lipophilicity/hydrosolubility and synthesized to assess their activity and selective toxicity towards the parasite. Results showed that this strategy contributed to improve the drug-likeness of the series while considerable impacts on potency were observed. The rational analysis of the obtained data led to the identification of seven active piperazine amides (28–34, IC50 8.7 to 35.3 µM against intracellular amastigotes), devoid of significant cytotoxicity to mammalian cells. The addition of water-solubilizing groups and privileged substructures such as piperazines improved the physicochemical properties and overall drug-likeness of these compounds, increased potency and maintained selectivity towards the parasite. The obtained results brought important structure-activity relationship (SAR) data and new lead structures for further modifications were identified to achieve improved antitrypanosoma compounds.
- ItemUma proposta de ensino interdisciplinar(Faculdade do Noroeste de Minas, 2022-02-10) Mota, Luiz Felipe Farias [UNIFESP]; Amorim, Vitor [UNIFESP]; Vieira, Rui Manoel de Bastos [UNIFESP]; http://lattes.cnpq.br/8397523106470083Este trabalho foi desenvolvido a partir de uma Iniciação Científica, sua aplicabilidade está voltada para um ensino de interdisciplinar capaz de integrar conceitos de física e música. Nossa proposta tem como objetivo apresentar uma proposta de ensino, na qual focamos em “no que ensinar", “como ensinar” e “por que ensinar". A proposta de ensino sugere a utilização práticas experimentais em sala de aula, para compô-las apresentamos os seguintes materiais disponíveis: um xilofone, um piano digital acompanhado de um conjunto de 4 teclados fabricados de papel, porém pintados com materiais diferentes, além de teclas “avulsas” constituídas de diversos materiais. A proposta tem a intenção de tornar evidente o diálogo entre o estudo de ondulatória e a produção de sons no xilofone e no piano digital, e dessa forma reforçar a ideia de que o saber se constitui como um todo e não de modo fragmentado.
- ItemFluorescence spectroscopy study of conventional and organic soybean oil heated to 270°C(IEEE, 2021-07-05) Lopes, Carla Regina Borges [UNIFESP]; Courrol, Lilia Coronato [UNIFESP]; Silva, Heron Dominguez Torres [UNIFESP]; http://lattes.cnpq.br/2967116316160694Edible vegetable oils are highly susceptible to lipid thermo-oxidation which results in the toxic substances production, with serious nutritional consequences. This work studies the fluorescence spectroscopy potential to determine oxidation status in these materials. The organic and conventional soybean oils fluorescence spectra have been studied and alterations were registered after heated at 270°C, Variations in chlorophyll fluorescence lifetime were analyzed to determine the pigment degradation. The results indicate that fluorescence spectroscopy is an efficient method to determine pigments degradation and increasing fatty acid oxidation products. It can be applied in the food industry and food quality control institutions.