Itens para a visualização no momento 1-20 of 15111

    • Systems analysis and improvement approach to optimize outpatient mental health treatment cascades in Mozambique (SAIA-MH): study protocol for a cluster randomized trial 

      Cumbe, Vasco Francisco Japissane [UNIFESP]; Muanido, Alberto Gabriel; Turner, Morgan; Ramiro, Isaias; Sherr, Kenneth; Weiner, Bryan J.; Flaherty, Brian P.; Sharma, Monisha; Faduque, Flávia; Xerinda, Ernesto Rodrigo; Wagenaar, Bradley H. (BMC_Implementation Science, 2022-06-06)
      Background: Significant investments are being made to close the mental health (MH) treatment gap, which often exceeds 90% in many low- and middle-income countries (LMICs). However, limited attention has been paid to patient ...

    • Community health workers’ knowledge, attitudes, and practices towards epilepsy in Sofala, central Mozambique 

      Cumbe, Vasco Francisco Japissane [UNIFESP]; Greene, Claire; Fumo, Afonso Mazine Tiago; Fumo, Hélder; Mabunda, Dirceu [UNIFESP]; Gouveia, Lídia Chaúque [UNIFESP]; Oquendo, Maria A.; Duarte, Cristiane S.; Sidat, Mohsin; Mari, Jair de Jesus[UNIFESP] (IJERPH_MDPI, 2022-11-21)
      Abstract: Background: Epilepsy is the most common neurological disease in the world, affecting 50 million people, with the majority living in low- and middle-income countries (LMICs). A major focus of epilepsy treatment ...

    • A randomized controlled trial on the use of pessary plus progesterone to prevent preterm birth in women with short cervical length (P5 trial) 

      Pacagnella, Rodolfo de Carvalho; Mol, Ben W.; Borovac-Pinheiro, Anderson; Passini Jr., Renato; Nomura, Marcelo Luís; Andrade, Kleber Cursino; Ellovitch, Nathalia; Fernandes, Karayna Gil; Bortoletto, Thaisa Guedes; Pereira, Cynara Maria; Miele, Maria Julia; França, Marcelo Santucci [UNIFESP]; Cecatti, José Guilherme; P5 Working Group (Springer Nature., 2019-11-27)
      Background: Preterm birth is the leading cause of mortality and disability in newborn and infants. Having a short cervix increases the risk of preterm birth, which can be accessed by a transvaginal ultrasound scan during ...

    • Pessary plus progesterone to prevent preterm birth in women with short cervixes. A randomized controlled trial 

      Pacagnella, Rodolfo de Carvalho; Silva, Thais V.; Cecatti, José Guilherme; Passini Jr., Renato; Fanton, Tatiana F.; Borovac-Pinheiro, Anderson; Pereira, Cynara Maria; Fernandes, Karayna Gil; França, Marcelo Santucci [UNIFESP]; Li, Wentao; Mol, Ben W.; P5 Working Group (Wolters Kluwer Health, Inc., 2022-01-01)
      OBJECTIVE: To test the effectiveness of cervical pessary in addition to vaginal progesterone for the prevention of preterm birth in women with midpregnancy short cervixes. METHODS: We performed a multicenter, ...

    • Prevalence and correlates of suicidal behavior in primary care settings in Mozambique 

      Cumbe, V. F. J. [UNIFESP]; Manaca, M. N.; Atkins, D. L.; Muanido, A.; Hicks, L.; Oquendo, M. A.; Jesus Mari, J. de [UNIFESP]; Wagenaar, B. H. (BMC Psychiatry, 2022-06-23)
      Background: This study assessed the prevalence of suicidal behavior and associated risk factors in public primary health care in Mozambique. Methods: The Mini-International Neuropsychiatric Interview was used to evaluate ...

    • Comparative phenotypic and genomic features of Staphylococci from sonication fluid of orthopedic implant-associated infections with poor outcome 

      Santos, Ingrid Nayara Marcelino [UNIFESP]; Kurihara, Mariana Neri Lucas [UNIFESP]; Santos, Fernanda Fernandes; Valiatti, Tiago Barcelos [UNIFESP]; Silva, Juliana Thalita Paulino [UNIFESP]; Pignatari, Antonio Carlos Campos [UNIFESP]; Salles, Mauro Jose Costa [UNIFESP] (MDPI, 2022-06-02)
      Staphylococcus spp. remain the leading biofilm-forming agents causing orthopedic im-plant-associated infections (OIAI). This is a descriptive study of phenotypic and genomic features identified in clinical isolates of S. ...

    • Cell-surface glycosaminoglycans regulate the cellular uptake of charged polystyrene nanoparticles 

      Olivieri Junior, Paulo Henrique [UNIFESP]; Jesus, Marcelo Bispo de; Nader, Helena Bonciani [UNIFESP]; Justo, Giselle Zenker; Sousa, Alioscka Augusto [UNIFESP] (Chunli Bai, 2022-05-02)
      Engineered nanoparticles approaching the cell body will first encounter and interact with cell-surface glycosaminoglycans (GAGs) before reaching the plasma membrane and becoming internalized. However, how surface GAGs may ...

    • Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring 

      Arida, Ricardo Mario [UNIFESP]; Lopim, Glauber Menezes [UNIFESP]; Gutierre, Robson Campos [UNIFESP]; Silva, Eduardo Alves da [UNIFESP] (Michele R. Brumley, 2020-03)
      Stress during gestation has been shown to affect susceptibility and intensity of seizures in offspring. Environmental stimuli, such as maternal physical exercise, have shown to be beneficial for brain development. Although ...

    • Validity and item response theory properties of the Patient Health Questionnaire-9 for primary care depression screening in Mozambique (PHQ-9-MZ) 

      Cumbe, Vasco F. J. [UNIFESP]; Muanido, Alberto; Manaca, Maria Nélia; Fumo, Hélder; Chiruca, Pedro; Hicks, Leecreesha; Mari, Jair de Jesus [UNIFESP]; Wagenaar, Bradley H. (BMC Psychiatry, 2020)
      Background: Depression is one of the leading causes of disability in Mozambique; however, few patients with depression are identified in primary care. To our knowledge, there are no validated tools for depression screening ...

    • Mitochondrial sirtuin TcSir2rp3 affects TcSODA activity and oxidative stress response in Trypanosoma cruzi 

      Moura, Leila dos Santos [UNIFESP]; Nunes, Vinícius Santana [UNIFESP]; Gomes, Antoniel A. S.; Sousa, Ana Caroline de Castro Nascimento [UNIFESP]; Fontes, Marcos R. M.; Schenkman, Sergio [UNIFESP]; Moretti, Nilmar Silvio [UNIFESP] (Frontiers, 2021)
      Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a !ne regulation of a complex antioxidant arsenal of enzymes. Reversible ...

    • Trypanosoma cruzi 

      Moretti, Nilmar Silvio [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Schenkman, Sergio [UNIFESP] (Cell Press, 2021)
      Trypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces ...

    • Protein acetylation in the critical biological processes in protozoan parasites 

      Maran, Suellen Rodrigues [UNIFESP]; Fleck, Krista; Monteiro-Teles, Natália Melquie; Isebe, Tony; Walrad, Pegine; Jeffers, Victoria; Cestari, Igor; Vasconcelos, Elton J.R.; Moretti, Nilmar [UNIFESP] (Cell Press, 2021)
      Protein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone ...

    • Epitranscriptome machinery in Trypanosomatids: new players on the table? 

      Maran, Suellen Rodrigues [UNIFESP]; Pitta, João Luiz de Lemos Padilha; Vasconcelos, Crhisllane Rafaele dos Santos; McDermott, Suzanne M.; Rezende, Antonio Mauro; Moretti, Nilmar Silvio (Wiley, 2021)
      Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, ...

    • Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania 

      Maran, Suellen Rodrigues [UNIFESP]; Bonifácio, Bruno Souza [UNIFESP]; Zanchetta, Myrna [UNIFESP]; Garcia, Miguel Antonio do Nascimento [UNIFESP]; Catta-Preta, Carolina M. C.; Moretti, Nilmar Silvio [UNIFESP] (JoVE, 2021)
      The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...

    • Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity 

      Leite, Ariely Barbosa [UNIFESP]; Gomes, Antoniel Augusto Severo; Sousa, Ana Caroline de Castro Nascimento [UNIFESP]; Fontes, Marcos Roberto de Mattos; Schenkman, Sergio [UNIFESP]; Moretti, Nilmar Silvio [UNIFESP] (Portland Press, 2020)
      Post-translational modifications provide suitable mechanisms for cellular adaptation to environmental changes. Lysine acetylation is one of these modifications and occurs with the addition of an acetyl group to Nε-amino ...

    • Raising the Bar(-seq) in Leishmania genetic screens 

      Ferreira, Tiago R.; Couñago, Rafael M.; Moretti, Nilmar Silvio [UNIFESP] (Cell Press, 2021)
      Our understanding of regulatory factors in Leishmania differentia- tion has long been restricted by the available genetic tools, but the availability of CRISPR/Cas9 has changed the landscape forever. Recently, Baker and ...

    • Chromatin proteomics reveals variable histone modifications during the life cycle of Trypanosoma cruzi 

      Jesus, Teresa Cristina Leandro de [UNIFESP]; Nunes, Vinícius Santana [UNIFESP]; Lopes, Mariana de Camargo; Martil, Daiana Evelin; Iwai, Leo Kei; Moretti, Nilmar Silvio [UNIFESP]; Machado, Fabrício Castro [UNIFESP]; De Lima-Stein, Mariana Leão [UNIFESP]; Thiemann, Otavio Henrique; Elias, Maria Carolina; Janzen, Christian; Schenkman, Sergio [UNIFESP]; Cunha, Julia Pinheiro Chagas da (ACS Publications, 2016)
      Histones are well-conserved proteins that form the basic structure of chromatin in eukaryotes and undergo several post-translational modifications, which are important for the control of transcription, replication, DNA ...

    • Chemogenetic characterization of inositol phosphate metabolic pathway reveals druggable enzymes for targeting kinetoplastid parasites 

      Cestari, Igor; Haas, Paige; Moretti, Nilmar Silvio [UNIFESP]; Schenkman, Sergio [UNIFESP]; Stuart, Ken (Cell Press, 2016)
      Kinetoplastids cause Chagas disease, human Afri- can trypanosomiasis, and leishmaniases. Current treatments for these diseases are toxic and ineffi- cient, and our limited knowledge of drug targets and inhibitors has ...

    • Preclinical gold complexes as oral drug candidates to treat leishmaniasis are potent Trypanothione reductase inhibitors 

      Tunes, Luiza G.; Morato, Roberta E.; Garcia, Adriana; Schmitz, Vinicius; Steindel, Mario; Correa-Junior, Jose A.D.; Santos, Helio F. Dos; Frezard, Frederic; Almeida, Mauro V. de; Silva, Heveline; Moretti, Nilmar S. [UNIFESP]; de Barros, Andre L. B.; Monte-Neto, Rubens L. do (ACS Publications, 2020)
      The drugs currently used to treat leishmaniases have limitations concerning cost, e!cacy, and safety, making the search for new therapeutic approaches urgent. We found that the gold(I)-derived complexes were active against ...

    • Characterization of Trypanosoma cruzi Sirtuins as possible drug targets for Chagas disease 

      Moretti, Nilmar Silvio [UNIFESP]; Augusto, Leonardo da Silva [UNIFESP]; Clemente, Tatiana Mordente [UNIFESP]; Antunes, Raysa Paes Pinto [UNIFESP]; Yoshida, Nobuko [UNIFESP]; Torrecilhas, Ana Claudia; Cano, Maria Isabel Nogueira; Schenkman, Sergio [UNIFESP] (ASM, 2015)
      Acetylation of lysine is a major posttranslational modification of proteins and is catalyzed by lysine acetyltransferases, while lysine deacetylases remove acetyl groups. Among the deacetylases, the sirtuins are NAD(+)-dependent ...