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Depression, Cytokine, and Cytokine by Treatment Interactions Modulate Gene Expression in Antipsychotic Naive First Episode Psychosis

Noto, Cristiano [UNIFESP]; Ota, Vanessa Kiyomi [UNIFESP]; Santoro, Marcos Leite [UNIFESP]; Gouvea, Eduardo Sauerbronn [UNIFESP]; Silva, Patricia Natalia [UNIFESP]; Spindola, Leticia Maria [UNIFESP]; Cordeiro, Quirino [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Gadelha, Ary [UNIFESP]; Brietzke, Elisa [UNIFESP]; Belangero, Sintia Iole [UNIFESP]; Maes, Michael (Humana Press Inc, 2016)

In schizophrenia, genetic and environmental factors affect neurodevelopment and neuroprogressive trajectory. Altered expression of neuro-immune genes and increased levels of cytokines are observed, especially in patients ...

Vitamin D deficiency and seasonal variation over the years in So Paulo, Brazil

Eloi, Marina [UNIFESP]; Horvath, Daniela Vargas [UNIFESP]; Szejnfeld, Vera Lucia [UNIFESP]; Ortega, João Carlos [UNIFESP]; Rocha, D. A. C.; Szejnfeld, Jacob [UNIFESP]; Castro, Charlles Heldan de Moura [UNIFESP] (Springer London Ltd, 2016)

Brazil is a tropical/subtropical geographic area with elevated ultraviolet (UV) radiation. We report very high prevalence of vitamin D deficiency in a large database of Brazilian subjects and show seasonal and reciprocal ...

Gene expression in blood of children and adolescents: MOediation between childhood maltreatment and major depressive disorder

Spindola, Leticia Maria [UNIFESP]; Pan, Pedro Mario [UNIFESP]; Moretti, Patricia Natalia [UNIFESP]; Ota, Vanessa Kiyomi [UNIFESP]; Santoro, Marcos Leite [UNIFESP]; Cogo-Moreira, Hugo [UNIFESP]; Gadelha, Ary [UNIFESP]; Salum, Giovanni; Manfro, Gisele Gus; Mari, Jair Jesus [UNIFESP]; Brentani, Helena; Grassi-Oliveira, Rodrigo; Brietzke, Elisa [UNIFESP]; Miguel, Euripedes Constantino; Rohde, Luis Augusto; Sato, Joao Ricardo; Bressan, Rodrigo Affonseca [UNIFESP]; Belangero, Sintia Iole [UNIFESP] (Pergamon-Elsevier Science Ltd, 2017)

Investigating major depressive disorder (MDD) in childhood and adolescence can help reveal the relative contributions of genetic and environmental factors to MDD, since early stages of disease have less influence of illness ...

Low-level laser therapy in IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendon

Jesus, Julio Fernandes de [UNIFESP]; Spadacci-Morena, Diva Denelle; Anjos Rabelo, Nayra Deise dos; Pinfildi, Carlos Eduardo [UNIFESP]; Fukuda, Thiago Yukio; Plapler, Helio [UNIFESP] (Springer, 2015-01-01)

This study evaluated IL-1 beta, COX-2, and PGE2 modulation in partially injured Achilles tendons treated with low-level laser therapy (LLLT). Sixty-five male Wistar rats were used. Sixty were submitted to a direct injury ...

Effects of acute aerobic exercise on leukocyte inflammatory gene expression in systemic lupus erythematosus

Perandini, L. A.; Sales-de-Oliveira, Diego; Almeida, D. C. [UNIFESP]; Azevedo, Hatylas; Moreira-Filho, C. A.; Cenedeze, Marco Antonio [UNIFESP]; Benatti, F. B.; Lima, F. R.; Borba, Eduardo; Bonfa, E.; Sa-Pinto, A. L.; Roschel, H.; Camara, N. O.; Gualano, B. (Centro Federal Educacao Tecnologica Rio Grande Norte, 2016)

Systemic lupus erythematosus (SLE) is an autoimmune disease with a persistent systemic inflammation. Exercise-induced inflammatory response in SLE remains to be fully elucidated. The aim of this study was to assess the ...

Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

Lira, Fabio Santos de [UNIFESP]; Yamashita, Alex S.; Rosa Neto, José Cesar [UNIFESP]; Tavares, Fabio L.; Caperuto, Erico; Carnevali, Luiz C.; Pimentel, Gustavo Duarte [UNIFESP]; Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]; Batista, Miguel L.; Laviano, Alessandro; Rossi-Fanelli, Filippo; Seelaender, Marilia (Biomed Central Ltd, 2011-08-24)

Aim: We tested the effects of a cancer cachexia-anorexia sydrome upon the balance of anti and pro-inflammatory cytokines in the hypothalamus of sedentary or trained tumour-bearing (Walker-256 carcinosarcoma) rats.Methods: ...

Roux-en-Y Gastric Bypass Decreases Pro-inflammatory and Thrombotic Biomarkers in Individuals with Extreme Obesity

Dal Molin Netto, Bárbara [UNIFESP]; Bettini, Solange Cravo; Clemente, Ana Paula Grotti [UNIFESP]; Ferreira, Joana Pereira de Carvalho [UNIFESP]; Boritza, Katia; Souza, Sandy de Fatima; Von der Heyde, Maria Emilia; Earthman, Carrie P.; Dâmaso, Ana Raimunda [UNIFESP] (Springer, 2015-06-01)

The low-grade inflammatory state in obesity leads to insulin resistance and endothelial dysfunction, which promote cardiovascular diseases in individuals with obesity. the purpose of this study was to evaluate the early ...

Sport-based physical activity recommendations and modifications in C-reactive protein and arterial thickness

Cayres, Suziane Ungari; Lira, Fabio Santos de [UNIFESP]; Kemper, Han C. G.; Codogno, Jamile Sanches; Barbosa, Mauricio Fregonesi [UNIFESP]; Fernandes, Romulo Araujo (Springer, 2018)

We analyzed the effects of 1 year of engagement in >= 300 min/week of organized sports on inflammatory levels and vascular structure in adolescents. The sample was composed of 89 adolescents (11.6 +/- 0.7 years old [43 ...

Association of serum interleukin-6 with mental health problems in children exposed to perinatal complications and social disadvantage

Mansur, Rodrigo B. [UNIFESP]; Cunha, Graccielle R. [UNIFESP]; Asevedo, Elson [UNIFESP]; Zugman, Andre [UNIFESP]; Rizzo, Lucas B. [UNIFESP]; Grassi-Oliveira, Rodrigo; Levandowski, Mateus L.; Gadelha, Ary [UNIFESP]; Pan, Pedro M. [UNIFESP]; Teixeira, Antonio L.; McIntyre, Roger S.; Mari, Jair J. [UNIFESP]; Rohde, Luis A.; Miguel, Euripedes C.; Bressan, Rodrigo A. [UNIFESP]; Brietzke, Elisa [UNIFESP] (Pergamon-Elsevier Science Ltd, 2016)

There is consistent evidence that inflammation is involved in mental disorders pathogenesis. Herein, using data from the High Risk Cohort Study for Psychiatric Disorders, we investigated the relationship between parental ...

Bone marrow mononuclear cells attenuate fibrosis development after severe acute kidney injury

Semedo, Patricia [UNIFESP]; Donizetti-Oliveira, Cassiano [UNIFESP]; Burgos-Silva, Marina [UNIFESP]; Cenedeze, Marco Antonio [UNIFESP]; Malheiros, Denise Maria Avancini Costa; Pacheco-Silva, Alvaro [UNIFESP]; Camara, Niels Olsen Saraiva [UNIFESP] (Nature Publishing Group, 2010-05-01)

One of the early phases that lead to fibrosis progression is inflammation. Once this stage is resolved, fibrosis might be prevented. Bone marrow mononuclear cells (BMMCs) are emerging as a new therapy for several pathologies, ...

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