Now showing items 1-10 of 42
Decreased nuclear distribution nudE-like 1 enzyme activity in an animal model with dysfunctional disrupted-in-schizophrenia 1 signaling featuring aberrant neurodevelopment and amphetamine-supersensitivity
Background: Interaction of nuclear-distribution element-like 1 with disrupted-in-schizophrenia 1 protein is crucial for neurite outgrowth/neuronal migration, and this interaction competitively inhibits nuclear-distribution ...
Quantitative mechanistic model for ultrasmall nanoparticle–protein interactions
(Royal Society of Chemistry, 2020-09-15)
To date, extensive effort has been devoted toward the characterization of protein interactions with synthetic nanostructures. However, much remains to be understood, particularly concerning microscopic mechanisms of ...
Ultrasmall gold nanoparticles coated with zwitterionic glutathione monoethyl ester: a model platform for the incorporation of functional peptides
(American Chemical Society, 2020-04-30)
Ultrasmall gold nanoparticles (AuNPs) are an emerging class of nanomaterials exhibiting distinctive physicochemical, molecular, and in vivo properties. Recently, we showed that ultrasmall AuNPs encompassing a zwitterionic ...
Lysine acetylation as drug target in fungi: an underexplored potential in Aspergillus spp.
In recent years, the intensification of the use of immunosuppressive therapies has increased the incidence of invasive infections caused by opportunistic fungi. Considering that, the spread of azole resistance and amphotericin ...
The threat of emerging and re-emerging pathogenic Sporothrix species
(Ferry Hagen, 2020-02-12)
Effects of psychostimulants and antipsychotics on serum lipids in an animal model for schizophrenia
(MDPI AG, 2021-02-26)
Schizophrenia (SCZ) treatment is essentially limited to the use of typical or atypical antipsychotic drugs, which suppress the main symptoms of this mental disorder. Metabolic syndrome is often reported in patients with ...
Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania
The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...
The current drug discovery landscape for trypanosomiasis and leishmaniasis: challenges and strategies to identify drug targets
(Willey Periodicals, 2020)
Human trypanosomiasis and leishmaniasis are vector-borne neglected tropical diseases caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp., respectively. Once restricted to endemic areas, ...
Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity
(Portland Press, 2020)
Post-translational modifications provide suitable mechanisms for cellular adaptation to environmental changes. Lysine acetylation is one of these modifications and occurs with the addition of an acetyl group to Nε-amino ...
Oxidative origin of sperm DNA fragmentation in the adult varicocele
(Brazilian Society of Urology– SBU, 2020-09-10)
Purpose: Sperm DNA fragmentation is a major cellular mechanism underlying varicocele-related male infertility. However, the type of DNA fragmentation - whether oxidative or of another nature - remains unknown. Thus, the ...