Recent Submissions

  • Prevalence and correlates of suicidal behavior in primary care settings in Mozambique 

    Cumbe, V. F. J. [UNIFESP]; Manaca, M. N.; Atkins, D. L.; Muanido, A.; Hicks, L.; Oquendo, M. A.; Jesus Mari, J. de [UNIFESP]; Wagenaar, B. H. (BMC Psychiatry, 2022-06-23)
    Background: This study assessed the prevalence of suicidal behavior and associated risk factors in public primary health care in Mozambique. Methods: The Mini-International Neuropsychiatric Interview was used to evaluate ...
  • Comparative phenotypic and genomic features of Staphylococci from sonication fluid of orthopedic implant-associated infections with poor outcome 

    Santos, Ingrid Nayara Marcelino [UNIFESP]; Kurihara, Mariana Neri Lucas [UNIFESP]; Santos, Fernanda Fernandes; Valiatti, Tiago Barcelos [UNIFESP]; Silva, Juliana Thalita Paulino [UNIFESP]; Pignatari, Antonio Carlos Campos [UNIFESP]; Salles, Mauro Jose Costa [UNIFESP] (MDPI, 2022-06-02)
    Staphylococcus spp. remain the leading biofilm-forming agents causing orthopedic im-plant-associated infections (OIAI). This is a descriptive study of phenotypic and genomic features identified in clinical isolates of S. ...
  • Cell-surface glycosaminoglycans regulate the cellular uptake of charged polystyrene nanoparticles 

    Olivieri Junior, Paulo Henrique [UNIFESP]; Jesus, Marcelo Bispo de; Nader, Helena Bonciani [UNIFESP]; Justo, Giselle Zenker; Sousa, Alioscka Augusto [UNIFESP] (Chunli Bai, 2022-05-02)
    Engineered nanoparticles approaching the cell body will first encounter and interact with cell-surface glycosaminoglycans (GAGs) before reaching the plasma membrane and becoming internalized. However, how surface GAGs may ...
  • Physical exercise during pregnancy minimizes PTZ-induced behavioral manifestations in prenatally stressed offspring 

    Arida, Ricardo Mario [UNIFESP]; Lopim, Glauber Menezes [UNIFESP]; Gutierre, Robson Campos [UNIFESP]; Silva, Eduardo Alves da [UNIFESP] (Michele R. Brumley, 2020-03)
    Stress during gestation has been shown to affect susceptibility and intensity of seizures in offspring. Environmental stimuli, such as maternal physical exercise, have shown to be beneficial for brain development. Although ...
  • Validity and item response theory properties of the Patient Health Questionnaire-9 for primary care depression screening in Mozambique (PHQ-9-MZ) 

    Cumbe, Vasco F. J. [UNIFESP]; Muanido, Alberto; Manaca, Maria Nélia; Fumo, Hélder; Chiruca, Pedro; Hicks, Leecreesha; Mari, Jair de Jesus [UNIFESP]; Wagenaar, Bradley H. (BMC Psychiatry, 2020)
    Background: Depression is one of the leading causes of disability in Mozambique; however, few patients with depression are identified in primary care. To our knowledge, there are no validated tools for depression screening ...
  • Mitochondrial sirtuin TcSir2rp3 affects TcSODA activity and oxidative stress response in Trypanosoma cruzi 

    Moura, Leila dos Santos [UNIFESP]; Nunes, Vinícius Santana [UNIFESP]; Gomes, Antoniel A. S.; Sousa, Ana Caroline de Castro Nascimento [UNIFESP]; Fontes, Marcos R. M.; Schenkman, Sergio [UNIFESP]; Moretti, Nilmar Silvio [UNIFESP] (Frontiers, 2021)
    Trypanosoma cruzi faces a variety of environmental scenarios during its life cycle, which include changes in the redox environment that requires a !ne regulation of a complex antioxidant arsenal of enzymes. Reversible ...
  • Trypanosoma cruzi 

    Moretti, Nilmar Silvio [UNIFESP]; Mortara, Renato Arruda [UNIFESP]; Schenkman, Sergio [UNIFESP] (Cell Press, 2021)
    Trypanosoma cruzi is the etiological agent of American trypanosomiasis, or Chagas disease, and is transmitted mainly by blood-sucking reduviid insects in endemic countries. Metacyclic trypomastigotes released in the feces ...
  • Protein acetylation in the critical biological processes in protozoan parasites 

    Maran, Suellen Rodrigues [UNIFESP]; Fleck, Krista; Monteiro-Teles, Natália Melquie; Isebe, Tony; Walrad, Pegine; Jeffers, Victoria; Cestari, Igor; Vasconcelos, Elton J.R.; Moretti, Nilmar [UNIFESP] (Cell Press, 2021)
    Protein lysine acetylation has emerged as a major regulatory post-translational modi!cation in different organisms, present not only on histone proteins affecting chromatin structure and gene expression but also on nonhistone ...
  • Epitranscriptome machinery in Trypanosomatids: new players on the table? 

    Maran, Suellen Rodrigues [UNIFESP]; Pitta, João Luiz de Lemos Padilha; Vasconcelos, Crhisllane Rafaele dos Santos; McDermott, Suzanne M.; Rezende, Antonio Mauro; Moretti, Nilmar Silvio (Wiley, 2021)
    Trypanosoma and Leishmania parasites cause devastating tropical diseases resulting in serious global health consequences. These organisms have complex life cycles with mammalian hosts and insect vectors. The parasites must, ...
  • Use of LeishGEdit CRISPR-Cas9 technology for genetic manipulation of protozoan parasite Leishmania 

    Maran, Suellen Rodrigues [UNIFESP]; Bonifácio, Bruno Souza [UNIFESP]; Zanchetta, Myrna [UNIFESP]; Garcia, Miguel Antonio do Nascimento [UNIFESP]; Catta-Preta, Carolina M. C.; Moretti, Nilmar Silvio [UNIFESP] (JoVE, 2021)
    The cell biology of a parasitic protozoan as well as the impact of the infection in host cells can be addressed using genome modification techniques. The development of robust methods eases the burden to obtain gene mutants ...

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