Recent Submissions

  • Assessment of the level of health literacy of drug users in the Primary Health Care of the Brazilian Unified Health System 

    Nappo, Solange Aparecida [UNIFESP]; Bigal, André Luiz [UNIFESP] (Dr. Ricardo Shitsuka, 2021-08-26)
    Patients’ knowledge and awareness of their disease and medication (health literacy) are essential to ensure treatment effectiveness. This work analyzed the health literacy (HL) level of users of the Brazilian Unified Health ...
  • Cross-sex testosterone therapy modifies the renal morphology and function in female rats and might underlie increased systolic pressure 

    Lichtenecker, Debora Conte Kimura [UNIFESP]; Rogerio, Argéri; Castro, Charlles Heldan de Moura; Dias-da-Silva, Magnus Regios; Gomes, Guiomar Nascimento (Blackwell Scientific Publications, 2021-03-12)
    Testosterone esters are hormones commonly used for affirming gender identity in transmen. The present study evaluates the effect of testosterone on renal morphology and function in an animal model submitted to cross-sex ...
  • CTPS forms the cytoophidium in zebrafish 

    Chang, Chia-Chun; Keppeke, Gerson Dierley [UNIFESP]; Antos, Christopher L.; Peng, Min; Andrade, Luis Eduardo Coelho [UNIFESP]; Sung, Li-Ying; Liu, Ji-Long (Andras Simon, 2021-08-15)
    Cytidine triphosphate synthase (CTPS) catalyzes the rate-limiting step of de novo CTP biosynthesis. An intracellular structure of CTPS, the cytoophidium, has been found in many organisms including prokaryotes and eukaryotes. ...
  • Caracterização estrutural de bicamadas catiônicas de DODAB contendo c24:1 beta-glicosilceramida 

    Martins, Leticia de Souza [UNIFESP]; Nomura, Daniela Akiko [UNIFESP]; Duarte, Evandro Luiz [UNIFESP]; Riske, Karin do Amaral [UNIFESP]; Lamy, Maria Teresa Moura [UNIFESP]; Rozenfeld, Julio Henrique Kravcuks [UNIFESP] (Elsevier, 2019-01-03)
    The effect of 5 mol%, 9 mol%, and 16 mol% of C24:1 β-glucosylceramide (βGlcCer) on the structure of cationic DODAB bilayers was investigated by means of differential scanning calorimetry (DSC), electron ...
  • Biomolecular interactions of ultrasmall metallic nanoparticles and nanoclusters 

    Ferreira, Rodrigo S [UNIFESP]; Lira, André L [UNIFESP]; Sousa, Alioscka A [UNIFESP] (Royal Society of Chemistry, 2021-04-28)
    The use of nanoparticles (NPs) in biomedicine has made a gradual transition from proof-of-concept to clinical applications, with several NP types meeting regulatory approval or undergoing clinical trials. A new type of ...
  • Regulation of thrombin activity with ultrasmall nanoparticles: effects of surface chemistry 

    Lira, André L [UNIFESP]; Ferreira, Rodrigo S [UNIFESP]; Oliva, Maria Luiza V. [UNIFESP]; Sousa, Alioscka A [UNIFESP] (American Chemical Society, 2020-06-26)
    Nanomaterials displaying well-tailored sizes and surface chemistries can provide novel ways with which to modulate the structure and function of enzymes. Recently, we showed that gold nanoparticles (AuNPs) in the ultrasmall ...
  • Ultrasmall gold nanoparticles coated with zwitterionic glutathione monoethyl ester: a model platform for the incorporation of functional peptides 

    Knittel, Luiza L; Zhao, Huaying; Nguyen, Ai; Miranda, Antonio; Schuck, Peter [UNIFESP]; Sousa, Alioscka A [UNIFESP] (American Chemical Society, 2020-04-30)
    Ultrasmall gold nanoparticles (AuNPs) are an emerging class of nanomaterials exhibiting distinctive physicochemical, molecular, and in vivo properties. Recently, we showed that ultrasmall AuNPs encompassing a zwitterionic ...
  • Quantitative mechanistic model for ultrasmall nanoparticle–protein interactions 

    Ferreira, Rodrigo S [UNIFESP]; Lira, André L [UNIFESP]; Sousa, Alioscka A [UNIFESP] (Royal Society of Chemistry, 2020-09-15)
    To date, extensive effort has been devoted toward the characterization of protein interactions with synthetic nanostructures. However, much remains to be understood, particularly concerning microscopic mechanisms of ...
  • Mechanistic Insights into Ultrasmall Gold Nanoparticle–Protein Interactions through Measurement of Binding Kinetics 

    Sousa, Alioscka A [UNIFESP]; Ferreira, Rodrigo S [UNIFESP]; Lira, André L [UNIFESP]; Torquato, Ricardo J. S. [UNIFESP]; Schuck, Peter [UNIFESP] (American Chemical Society, 2019-10-28)
    Gold nanoparticles (NPs) in the ultrasmall size regime provide a new paradigm in the way that nanomaterials can be used to regulate protein structure and function. However, the rational design of ultrasmall NPs as viable ...
  • Allosteric inhibition of a-thrombin enzymatic activity with ultrasmall gold nanoparticles 

    Lira, André [UNIFESP]; Ferreira, Rodrigo [UNIFESP]; Torquato, Ricardo [UNIFESP]; Oliva, Maria L.V. [UNIFESP]; Schuck, Peter; Sousa, Alioscka A [UNIFESP] (Royal Society of Chemistry, 2018-09-24)
    The catalytic activity of enzymes can be regulated by interactions with synthetic nanoparticles (NPs) in a number of ways. To date, however, the potential use of NPs as allosteric effectors has not been investigated in ...
  • Oxidative origin of sperm DNA fragmentation in the adult varicocele 

    Jeremias, Jessica Timóteo; Belardin, Larissa Berloffa; Okada, Fatima Kazue; Antoniassi, Mariana Pereira; Fraietta, Renato; Bertolla, Ricardo Pimenta; Intasqui, Paula (Brazilian Society of Urology– SBU, 2020-09-10)
    Purpose: Sperm DNA fragmentation is a major cellular mechanism underlying varicocele-related male infertility. However, the type of DNA fragmentation - whether oxidative or of another nature - remains unknown. Thus, the ...
  • The dual effect of paradoxical sleep deprivation on murine immune functions 

    Sa-Nunes, Anderson; Bizzarro, Bruna; Egydio, Flavia [UNIFESP]; Barros, Michele S.; Sesti-Costa, Renata; Soares, Elyara M.; Pina, Adriana; Russo, Momtchilo; Faccioli, Lucia H.; Tufik, Sergio [UNIFESP]; Andersen, Monica L. [UNIFESP] (Elsevier Science Bv, 2016)
    We aimed to evaluate the effect of paradoxical sleep deprivation on the cellular migration during inflammation, the peritoneal macrophage phenotype and the infectious stimulus outcomes. A/J mice were inoculated with ...
  • Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring 

    da Silva, Sergio Gomes [UNIFESP]; de Almeida, Alexandre Aparecido [UNIFESP]; Fernandes, Jansen [UNIFESP]; Lopim, Glauber Menezes [UNIFESP]; Cabral, Francisco Romero; Scerni, Debora Amado [UNIFESP]; de Oliveira-Pinto, Ana Virginia; Lent, Roberto; Arida, Ricardo Mario [UNIFESP] (Public Library Science, 2016)
    Clinical evidence has shown that physical exercise during pregnancy may alter brain development and improve cognitive function of offspring. However, the mechanisms through which maternal exercise might promote such effects ...
  • Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X 

    Pacheco, Mario T. F.; Morais, Katia L. P. [UNIFESP]; Berra, Carolina M.; Demasi, Marilene; Sciani, Juliana M.; Branco, Vania G.; Bosch, Rosemary V.; Iqbal, Asif; Chudzinski-Tavassi, Ana Marisa (Elsevier Inc, 2016)
    The Kunitz-type recombinant protein, Amblyomin-X, is an antitumor recombinant molecule from a cDNA library prepared from the salivary glands of the tick Amblyomma cajennense. The primary target of this protein appears to ...
  • Efficient Condensation of DNA into Environmentally Responsive Polyplexes Produced from Block Catiomers Carrying Amine or Diamine Groups 

    Albuquerque, Lindomar J. C.; Annes, Kelly; Milazzotto, Marcella P.; Mattei, Bruno [UNIFESP]; Riske, Karin A. [UNIFESP]; Jaeger, Eliezer; Panek, Jiri; Stepanek, Petr; Kapusta, Peter; Muraro, Paulo I. R.; De Freitas, Augusto G. O.; Schmidt, Vanessa; Giacomelli, Cristiano; Bonvent, Jean-Jacques; Giacomelli, Fernando C. (Amer Chemical Soc, 2016)
    The intracellular delivery of nucleic acids requires a vector system as they cannot diffuse across lipid membranes. Although polymeric transfecting agents have been extensively investigated, none of the proposed gene ...
  • Conservative Treatment of Stress Urinary Incontinence: A Systematic Review with Meta-analysis of Randomized Controlled Trials 

    Moroni, Rafael Mendes; Magnani, Pedro Sergio; Haddad, Jorge Milhem; Castro, Rodrigo de Aquino [UNIFESP]; Brito, Luiz Gustavo Oliveira (Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2016)
    We performed a systematic review and meta-analysis of randomized controlled trials that studied the conservative management of stress urinary incontinence (SUI). There were 1058 results after the initial searches, from ...
  • Gastroesophageal reflux disease in the obese: Pathophysiology and treatment 

    Nadaleto, Barbara F. [UNIFESP]; Herbella, Fernando A. M. [UNIFESP]; Patti, Marco G. (Mosby-Elsevier, 2016)
    Obesity is a condition that has increased all over the world in the last 3 decades. Overweight and gastroesophageal reflux disease (GERD) are related. GERD may have different causative factors in the obese compared with ...
  • Inflammation, neurotrophism and oxidative stress and childhood psychopathology in a large community sample 

    Cunha, G. R. [UNIFESP]; Asevedo, E. [UNIFESP]; Mansur, R. B. [UNIFESP]; Zugman, A. [UNIFESP]; Pan, P. M. [UNIFESP]; Gadelha, A. [UNIFESP]; Belangero, S. I. [UNIFESP]; Rizzo, L. B. [UNIFESP]; Coelho, R.; Stertz, L.; Cogo-Moreira, H. [UNIFESP]; Grassi-Oliveira, R.; Teixeira, A. L.; Kauer-Sant'Anna, M.; Mari, J. J. [UNIFESP]; Miguel, E. C.; Bressan, R. A. [UNIFESP]; Brietzke, E. [UNIFESP] (Wiley, 2016)
    Objective: To investigate the association between peripheral biomarkers and child psychopathology in a large community sample. Method: A total of 625 aged 6- to 13-year old subjects were recruited from a community school-based ...
  • Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates 

    Chudzinski-Tavassi, Ana Marisa; Morais, Katia L. P. [UNIFESP]; Pacheco, Mario Thiego Fernandes; Pasqualoto, Kerly Fernanda Mesquita; de Souza, Jean Gabriel [UNIFESP] (Elsevier France-Editions Scientifiques Medicales Elsevier, 2016)
    Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its ...

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