Now showing items 1-10 of 151
A multifunctional serine protease primes the malaria parasite for red blood cell invasion
(Nature Publishing Group, 2009-03-18)
The malaria parasite Plasmodium falciparum replicates within an intraerythrocytic parasitophorous vacuole (PV). Rupture of the host cell allows release (egress) of daughter merozoites, which invade fresh erythrocytes. We ...
The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
(Elsevier B.V., 2013-05-01)
We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)-producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the ...
Trypanosoma brucei Metacaspase 4 Is a Pseudopeptidase and a Virulence Factor
(Amer Soc Biochemistry Molecular Biology Inc, 2011-11-18)
Metacaspases are caspase family cysteine peptidases found in plants, fungi, and protozoa but not mammals. Trypanosoma brucei is unusual in having five metacaspases (MCA1-MCA5), of which MCA1 and MCA4 have active site ...
Identification of potential vaccine T cell epitopes based on computer selected sequences
Leviserpin: A Serine Peptidase Inhibitor (Serpin) from the Sugarcane Weevil Sphenophorus levis
Serine peptidase inhibitors (serpins) form a superfamily of proteins covering abroad spectrum of different biological functions. Here we describe the inhibitory characterization of leviserpin, the first serpin from the ...
Isomannide derivatives as new class of inhibitors for human kallikrein 7
(Elsevier B.V., 2012-10-01)
Human kallikrein 7 (KLK7) is a potential target for the treatment of skin inflammation and cancer. Despite its potential, few KLK7-specific small-molecule inhibitors have been reported in the literature. As an extension ...
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates
(Portland Press Ltd, 2005-01-15)
APP (aminopeptidase P) has the unique ability to cleave the N-terminal amino acid residue from peptides exhibiting a proline at P-1'. Despite its putative involvement in the processing of bioactive peptides, among them the ...
PURIFICATION AND CHARACTERIZATION OF A DYNORPHIN-PROCESSING ENDOPEPTIDASE
(Amer Soc Biochemistry Molecular Biology Inc, 1995-10-06)
Dynorphin B (Dyn B-13, also known as rimorphin) is generated from Dyn B-29 (leumorphin) by the cleavage at a single Arg residue. An enzymatic activity capable of processing at this monobasic site has been previously reported ...
Metagenomic Analysis of a Tropical Composting Operation at the São Paulo Zoo Park Reveals Diversity of Biomass Degradation Functions and Organisms
(Public Library Science, 2013-04-24)
Composting operations are a rich source for prospection of biomass degradation enzymes. We have analyzed the microbiomes of two composting samples collected in a facility inside the São Paulo Zoo Park, in Brazil. All organic ...
Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by amyloid beta
(Amer Soc Biochemistry Molecular Biology Inc, 2005-09-02)
Alzheimer disease ( AD) is characterized by accumulation of the neurotoxic amyloid beta peptide ( A beta) and by the loss of cholinergic neurons and nicotinic acetylcholine receptors ( nAChRs) throughout the brain. Direct ...