Manufatura aditiva de scaffolds de fosfatos de cálcio visando aplicação na engenharia tecidual
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Data
2021-02-23
Autores
Batista, Larissa Anne Pereira dos Santos [UNIFESP]
Orientadores
Albers, Ana Paula Fonseca [UNIFESP]
Tipo
Trabalho de conclusão de curso de graduação
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Resumo
Os fosfatos de cálcio são muito utilizados como biomaterial para a regeneração de tecidos duros, como os ossos, pois sua biocompatibilidade e biodegradabilidade, os tornam materiais promissores na confecção de scaffods para a engenharia tecidual. No entanto, projetar, dimensionar e aplicar esse material com a arquitetura e propriedades mecânicas necessárias para a regeneração e crescimento ósseo é tarefa árdua para a engenharia tecidual. A fabricação do scaffolds biocerâmicos devem compreender requisitos que correspondem a estrutura do osso, sendo ela cortical na superfície e trabecular no seu interior; podem ser fabricados por uma infinidade de técnicas de conformação, desde as técnicas clássicas, que já estão consolidadas no meio acadêmico, até técnicas avançadas de manufatura aditiva. O presente trabalho traz uma revisão bibliográfica integrativa acerca das principais técnicas de manufatura aditiva para a engenharia tecidual, com enfoque no material de β-fosfato tricálcico, apresenta uma análise qualitativa das principais técnicas de manufatura aditiva e uma análise quantitativa das publicações referentes ao tema, apresentando o crescimento temporal dessas técnicas relacionadas a engenharia tecidual, buscando identificar tendências e nortear projetos futuros.
Calcium phosphates are widely used as a biomaterial for the regeneration of hard tissues, such as bones, due to their biological characteristics of biocompatibility and biodegradability, which make them promising materials for scaffolds manufacturing to be used in tissue engineering. However, designing, dimensioning and applying this material with the necessary architecture and mechanical properties for bone regeneration and growth are arduous tasks for tissue engineering. Processing bioceramic scaffolds must include requirements that correspond to the bone structure, with cortical characteristics on the surface and trabecular in its interior; they can be made using a lot of manufacturing process, since conventional techniques, already well known in academic environment, until advanced additive manufacturing techniques. The present research shows an integrative review based on main additive manufacturing techniques for tissue engineering, focusing on β - tricalcium phosphate, and performs a qualitative analysis of the main AM techniques and a quantitative analysis of articles related to the theme, presenting the temporal growth of these techniques and tissue engineering, seeking to identify trends and guide future projects.
Calcium phosphates are widely used as a biomaterial for the regeneration of hard tissues, such as bones, due to their biological characteristics of biocompatibility and biodegradability, which make them promising materials for scaffolds manufacturing to be used in tissue engineering. However, designing, dimensioning and applying this material with the necessary architecture and mechanical properties for bone regeneration and growth are arduous tasks for tissue engineering. Processing bioceramic scaffolds must include requirements that correspond to the bone structure, with cortical characteristics on the surface and trabecular in its interior; they can be made using a lot of manufacturing process, since conventional techniques, already well known in academic environment, until advanced additive manufacturing techniques. The present research shows an integrative review based on main additive manufacturing techniques for tissue engineering, focusing on β - tricalcium phosphate, and performs a qualitative analysis of the main AM techniques and a quantitative analysis of articles related to the theme, presenting the temporal growth of these techniques and tissue engineering, seeking to identify trends and guide future projects.
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Citação
BATISTA, Larissa Anne Pereira dos Santos. Manufatura aditiva de scaffolds de fosfatos de cálcio visando aplicação na engenharia tecidual. Trabalho de Conclusão de curso. Universidade Federal de São Paulo, 2021.