Terapia interdisciplinar com uso de ferramentas digitais na obesidade: associação entre potencial inflamatório da alimentação, leptina e adiponectina em mulheres adultas
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Data
2020-11-27
Autores
Godoi, Viviane Luise Moura de [UNIFESP]
Orientadores
Caranti, Danielle Arisa [UNIFESP]
Tipo
Dissertação de mestrado
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Introdução: Nos últimos 13 anos, a obesidade sofreu um crescimento de 72% no Brasil. É considerada uma doença multifatorial, poligênica e também caracterizada por um baixo grau de inflamação crônica no TAB – Tecido Adiposo Branco. Um grande conjunto de evidências indica que a dieta desempenha um papel central na regulação desta inflamação, e o trabalho interdisciplinar em promoção da saúde constitui uma estratégia promissora para o enfrentamento desta doença. Objetivo: Avaliar o efeito de uma terapia interdisciplinar com uso de ferramentas digitais no índice inflamatório da dieta e nos marcadores inflamatórios adiponectina e leptina de um grupo de mulheres obesas. Métodos: Estudo clínico de caráter longitudinal com mulheres obesas (n=13), idade entre 20-45 anos, IMC: 30-39,9 kg/m2. Utilizou-se o Registro Alimentar de 3 dias e o software DietSmart® para determinar as variáveis dietéticas e IID (Shivappa et al, 2015) para avaliar o perfil inflamatório da dieta. Índice de massa corporal (IMC), perímetro abdominal (PA), quadril (PQ) e pescoço (PP), e composição corporal por impedância bioelétrica para determinação de adiposidade corporal. Amostras de sangue coletadas das voluntárias para análise dos marcadores inflamatórios. A terapia contou com mensagens educativas disponibilizadas através de aplicativos relacionados a celulares android, e intervenções interdisciplinares presenciais. Para avaliar os efeitos da terapia sobre os parâmetros analisados realizou-se teste t-Student para variáveis paramétricas e teste de Wilcoxon para as variáveis não paramétricas. Aplicou-se Teste de correlação de Pearson ou Spearman para verificar possível correlação entre as variáveis estudadas. Resultados: Houve uma redução significativa no perímetro abdominal (-1,6%; p= 0,05) e do pescoço (-1,1%; p=0,03). Quanto ao consumo alimentar, houve redução do DII da dieta (5,56 ± 2,10 para 4,08 ± 2,21; p=0,016), do consumo de calorias (1891,97 ± 417,25 para 1426,49 ±232,71; p=0,002), carboidratos (223,18 ± 61,19 para 162,99 ± 39,17; p=0,003), lipídeos (75,41 ± 21,26 para 51,63 ± 16,87; p=0,003), foi verificado aumento do consumo de proteínas (17,88 ± 3,39 para 22,3 ± 6,15; p=0,007). Não foi observada mudança significativa nas concentrações séricas basal e final de Leptina e Adiponectina. Conclusões: A terapia interdisciplinar com uso de ferramentas digitais demonstrou efeito positivo no DII da dieta, bem como redução das medidas antropométricas PA e PP, do consumo de calorias, lipídeos e carboidratos associado a um aumento do consumo de proteínas. O que confirma a importância da terapia interdisciplinar para o tratamento da obesidade.
Introduction: In the last 13 years, obesity has grown by 72% in Brazil. It is considered a multifactorial, polygenic disease and also characterized by a low degree of chronic inflammation in TAB - White Adipose Tissue. A large body of evidence indicates that diet plays a central role in regulating this inflammation, and interdisciplinary work in promoting health is a promising strategy for coping with this disease. Objective: To evaluate the effect of an interdisciplinary therapy using digital tools on the inflammatory index of the diet and on the inflammatory markers adiponectin and leptin in a group of obese women. Methods: Longitudinal clinical study with obese women (n = 13), age between 20-45 years, BMI: 30-39, 9 kg / m2. The 3-day Food Record and the DietSmart® software were used to determine the dietary variables and IID (Shivappa et al, 2015) to assess the inflammatory profile of the diet. Body mass index (BMI), abdominal perimeter (BP), hip (PQ) and neck (PP), and body composition by bioelectrical impedance to determine body adiposity. Blood samples collected from volunteers for analysis of inflammatory markers. The therapy had educational messages made available through applications related to android phones, and interdisciplinary interventions in person. To assess the effects of therapy on the parameters analyzed, Student's t test was performed for parametric variables and Wilcoxon test for non-parametric variables. Pearson's or Spearman's correlation test was applied to verify possible correlation between the variables studied. Results: There was a significant reduction in the abdominal perimeter (-1.6%; p = 0.05) and in the neck (-1.1%; p = 0.03). Regarding food consumption, there was a reduction in the diet's DII (5.56 ± 2.10 to 4.08 ± 2.21; p = 0.016), in calorie consumption (1891.97 ± 417.25 to 1426.49 ± 232.71; p = 0.002), carbohydrates (223.18 ± 61.19 for 162.99 ± 39.17; p = 0.003), lipids (75.41 ± 21.26 for 51.63 ± 16.87; p = 0.003), there was an increase in protein consumption (17.88 ± 3.39 to 22.3 ± 6.15; p = 0.007). No significant change was observed in the basal and final serum concentrations of Leptin and Adiponectin. Conclusions: Interdisciplinary therapy with the use of digital tools demonstrated a positive effect on the diet's DII, as well as a reduction in the anthropometric measures PA and PP, the consumption of calories, lipids and carbohydrates associated with an increase in the consumption of proteins. This confirms the importance of interdisciplinary therapy for the treatment of obesity.
Introduction: In the last 13 years, obesity has grown by 72% in Brazil. It is considered a multifactorial, polygenic disease and also characterized by a low degree of chronic inflammation in TAB - White Adipose Tissue. A large body of evidence indicates that diet plays a central role in regulating this inflammation, and interdisciplinary work in promoting health is a promising strategy for coping with this disease. Objective: To evaluate the effect of an interdisciplinary therapy using digital tools on the inflammatory index of the diet and on the inflammatory markers adiponectin and leptin in a group of obese women. Methods: Longitudinal clinical study with obese women (n = 13), age between 20-45 years, BMI: 30-39, 9 kg / m2. The 3-day Food Record and the DietSmart® software were used to determine the dietary variables and IID (Shivappa et al, 2015) to assess the inflammatory profile of the diet. Body mass index (BMI), abdominal perimeter (BP), hip (PQ) and neck (PP), and body composition by bioelectrical impedance to determine body adiposity. Blood samples collected from volunteers for analysis of inflammatory markers. The therapy had educational messages made available through applications related to android phones, and interdisciplinary interventions in person. To assess the effects of therapy on the parameters analyzed, Student's t test was performed for parametric variables and Wilcoxon test for non-parametric variables. Pearson's or Spearman's correlation test was applied to verify possible correlation between the variables studied. Results: There was a significant reduction in the abdominal perimeter (-1.6%; p = 0.05) and in the neck (-1.1%; p = 0.03). Regarding food consumption, there was a reduction in the diet's DII (5.56 ± 2.10 to 4.08 ± 2.21; p = 0.016), in calorie consumption (1891.97 ± 417.25 to 1426.49 ± 232.71; p = 0.002), carbohydrates (223.18 ± 61.19 for 162.99 ± 39.17; p = 0.003), lipids (75.41 ± 21.26 for 51.63 ± 16.87; p = 0.003), there was an increase in protein consumption (17.88 ± 3.39 to 22.3 ± 6.15; p = 0.007). No significant change was observed in the basal and final serum concentrations of Leptin and Adiponectin. Conclusions: Interdisciplinary therapy with the use of digital tools demonstrated a positive effect on the diet's DII, as well as a reduction in the anthropometric measures PA and PP, the consumption of calories, lipids and carbohydrates associated with an increase in the consumption of proteins. This confirms the importance of interdisciplinary therapy for the treatment of obesity.
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GODOI, Viviane Luise Moura de. Terapia interdisciplinar com uso de ferramentas digitais na obesidade: associação entre potencial inflamatório da alimentação, leptina e adiponectina em mulheres adultas. 2020. 100 f. Dissertação (Mestrado Interdisciplinar em Ciências da Saúde) - Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Santos, 2020.