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dc.contributor.authorFontes Silva, Giselle Melo [UNIFESP]
dc.contributor.authorPedroso, Jose Luiz [UNIFESP]
dc.contributor.authorDos Santos, Diogo Fernandes [UNIFESP]
dc.contributor.authorBraga-Neto, Pedro [UNIFESP]
dc.contributor.authorPrado, Lucila Bizari Fernandes Do [UNIFESP]
dc.contributor.authorCarvalho, Luciane Bizari Coin De [UNIFESP]
dc.contributor.authorBarsottini, Orlando G. P. [UNIFESP]
dc.contributor.authorDo Prado, Gilmar Fernandes [UNIFESP]
dc.date.accessioned2020-10-30T18:46:36Z
dc.date.available2020-10-30T18:46:36Z
dc.date.issued2016
dc.identifierhttps://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12330
dc.identifier.citationJournal Of Sleep Research. Hoboken, v. 25, n. 1, p. 11-15, 2016.
dc.identifier.issn0962-1105
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58530
dc.description.abstractSpinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3)MJD/SCA3is the most common SCA worldwide. MJD/SCA3 is characterized classically by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common, and include rapid eye movement (REM) sleep behaviour disorder (RBD), restless legs syndrome (RLS), insomnia, excessive daytime sleepiness, excessive fragmentary myoclonus and sleep apnea. This study aims to focus upon determining the presence or not of non-REM (NREM)-related parasomnias in MJD/SCA 3, using data from polysomnography (PSG) and clinical evaluation. Forty-seven patients with clinical and genetic diagnosis of MJD/SCA3 and 47 control subjects were evaluated clinically and by polysomnography. MJD/SCA3 patients had a higher frequency of arousals from slow wave sleep (P<0.001), parasomnia complaints (confusional arousal/sleep terrors, P=0.001; RBD, P<0.001; and nightmares, P<0.001), REM sleep without atonia (P<0.001), periodic limb movements of sleep index (PLMSi) (P<0.001), percentage of N3 sleep (P<0.001) and percentage of N1 sleep (P<0.001). These data show that NREM-related parasomnias must be included in the spectrum of sleep disorders in MJD/SCA3 patients.en
dc.format.extent11-15
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Sleep Research
dc.rightsAcesso aberto
dc.subjectMachado-Joseph diseaseen
dc.subjectNREM-related parasomniasen
dc.subjectpolysomnographyen
dc.subjectsleep disordersen
dc.subjectspinocerebellar ataxia type 3en
dc.titleNREM-related parasomnias in Machado-Joseph disease: clinical and polysomnographic evaluationen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Dept Neurol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Neurol, Sao Paulo, Brazil
dc.identifier.doi10.1111/jsr.12330
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000367618900003
dc.coverageHoboken
dc.citation.volume25
dc.citation.issue1


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