Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

Author Chudzinski-Tavassi, Ana Marisa Google Scholar
Morais, Katia L. P. Autor UNIFESP Google Scholar
Pacheco, Mario Thiego Fernandes Google Scholar
Pasqualoto, Kerly Fernanda Mesquita Google Scholar
de Souza, Jean Gabriel Autor UNIFESP Google Scholar
Abstract Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its saliva has a very rich variety of bioactive molecules. For instance, a Kunitz-type FXa inhibitor, named Amblyomin-X, was found through transcriptome of the salivary gland of the Amblyomma cajennense. tick. This TFPI-like inhibitor, after obtained as recombinant protein, has presented anticoagulant, antigionenic, and antitumor properties. Although its effects on blood coagulation could be relevant for antitumor effect, Amblyomin-X acts by non-hemostatic mechanisms, such as proteasome inhibition and autophagy inhibition. Notably, cytotoxicity was not observed on non-tumor cells treated with this protein, suggesting some selectivity for tumor cells. Considering the current efforts in order to develop effective anticancer therapies, the findings presented in this review strongly suggest Amblyomin-X as a promising novel antitumor drug candidate. (C) 2015 Elsevier Masson SAS. All rights reserved.
Keywords Amblyomin-X
TFPI-like
Proteasome inhibitor
Autophagy inhibition
Antitumor drug candidate
Anticoagulant
xmlui.dri2xhtml.METS-1.0.item-coverage Issy-Les-Moulineaux
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Grant number FAPESP: 2010/52669-3
FAPESP: 2010/07958-7
FAPESP: 2011/05969-4
FAPESP CAT/CEPID: 1998/14307-9
FAPESP CETICs: 2013/07467-1
Date 2016
Published in Biomedicine & Pharmacotherapy. Issy-Les-Moulineaux, v. 77, p. 14-19, 2016.
ISSN 0753-3322 (Sherpa/Romeo, impact factor)
Publisher Elsevier France-Editions Scientifiques Medicales Elsevier
Extent 14-19
Origin https://doi.org/10.1016/j.biopha.2015.11.003
Access rights Closed access
Type Article
Web of Science ID WOS:000368104100003
URI https://repositorio.unifesp.br/handle/11600/58520

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