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dc.contributor.authorSwardfager, Walter
dc.contributor.authorYu, Di
dc.contributor.authorScola, Gustavo
dc.contributor.authorCogo-Moreira, Hugo [UNIFESP]
dc.contributor.authorChan, Parco
dc.contributor.authorZou, Yi
dc.contributor.authorHerrmann, Nathan
dc.contributor.authorLanctot, Krista L.
dc.contributor.authorRamirez, Joel
dc.contributor.authorGao, Fuqiang
dc.contributor.authorMasellis, Mario
dc.contributor.authorSwartz, Richard H.
dc.contributor.authorSahlas, Demetrios J.
dc.contributor.authorChan, Pak Cheung
dc.contributor.authorOjeda-Lopez, Carmen
dc.contributor.authorMilan-Tomas, Angela
dc.contributor.authorPettersen, Jacqueline A.
dc.contributor.authorAndreazza, Ana C.
dc.contributor.authorBlack, Sandra E.
dc.identifier.citationNeurobiology Of Aging. New York, v. 59, p. 91-97, 2017.
dc.description.abstractSubcortical white matter hyperintensities (WMH), presumed to indicate small vessel ischemic vascular disease, are found commonly in elderly individuals with and without Alzheimer's disease (AD). Oxidative stress may instigate or accelerate the development of vascular disease, and oxidative stress markers are elevated in AD. Here, we assess independent relationships between three serum lipid peroxidation markers (lipid hydroperoxides [LPH], 8-isoprostane, and 4-hydroxynonenal) and the presence of extensive subcortical WMH and/or AD. Patients were recruited from memory and stroke prevention clinics into four groups: minimal WMH, extensive WMH, AD with minimal WMH, and AD with extensive WMH. Extensive WMH, but not AD, was associated with higher serum concentrations of 8-isoprostane and LPH. Peripheral LPH concentrations mediated the effect of hypertension on deep, but not periventricular, WMH volumes. 4-hydroxynonenal was associated with hyperlipidemia and cerebral micro-bleeds, but not with extensive WMH or AD. We conclude that lipid peroxidation mediates hypertensive injury to the deep subcortical white matter and that peripheral blood lipid peroxidation markers indicate subcortical small vessel disease regardless of an AD diagnosis. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipCanadian Partnership for Stroke Recovery
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipAlzheimer's Association (USA)
dc.description.sponsorshipBrain Canada
dc.description.sponsorshipAlzheimer's Association (US)
dc.description.sponsorshipBrain Canada
dc.description.sponsorshipSunnybrook Health Sciences Centre Department of Psychiatry
dc.description.sponsorshipSunnybrook Research Institute
dc.description.sponsorshipUniversity of Toronto Department of Pharmacology Toxicology
dc.description.sponsorshipCentre for Collaborative Drug Research
dc.description.sponsorshipFondation Leducq
dc.description.sponsorshipCanadian Institutes of Health Research
dc.description.sponsorshipHeart & Stroke Foundation Canadian Partnership for Stroke Recovery
dc.description.sponsorshipLinda C. Campbell Foundation
dc.description.sponsorshipCanadian Vascular Network
dc.description.sponsorshipOntario Brain Institute's Ontario Neurodegenerative Disease Research Initiative
dc.description.sponsorshipSunnybrook Health Sciences Centre Department of Medicine
dc.description.sponsorshipBrill Chair Neurology
dc.description.sponsorshipUniversity of Toronto
dc.description.sponsorshipHeart and Stroke Foundation
dc.description.sponsorshipOntario Brain Institute (ONDRI)
dc.description.sponsorshipDepartments of Medicine at the University of Toronto
dc.description.sponsorshipSunnybrook Health Sciences Centre
dc.description.sponsorshipBrill Chair in Neurology at Sunnybrook
dc.publisherElsevier Science Inc
dc.relation.ispartofNeurobiology Of Aging
dc.rightsAcesso restrito
dc.subjectSmall vessel diseaseen
dc.subjectCerebrovascular diseaseen
dc.subjectOxidative stressen
dc.subjectWhite matter hyperintensitiesen
dc.titlePeripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel diseaseen
dc.description.affiliationSunnybrook Res Inst, Hurvitz Brain Sci Program, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada
dc.description.affiliationSunnybrook Res Inst, Canadian Partnership Stroke Recovery, Toronto, ON, Canada
dc.description.affiliationSunnybrook Res Inst, LC Campbell Cognit Neurol Unit, Toronto, ON, Canada
dc.description.affiliationUniv Hlth Network, Toronto Rehabil Inst, Cardiovasc Prevent & Rehabil Program, Toronto, ON, Canada
dc.description.affiliationCtr Addict & Mental Hlth, Anxiety & Mood Disorders Dept, Toronto, ON, Canada
dc.description.affiliationUniv Toronto, Dept Psychiat, Toronto, ON, Canada
dc.description.affiliationUniv Fed Sao Paulo, Dept Psiquiatria, Sao Paulo, Brazil
dc.description.affiliationUniv Toronto, Neurol Div, Dept Med, Toronto, ON, Canada
dc.description.affiliationMcMaster Univ, Neurol Div, Dept Med, Hamilton, ON, Canada
dc.description.affiliationUniv Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
dc.description.affiliationSunnybrook Hlth Sci Ctr, Dept Clin Pathol, Toronto, ON, Canada
dc.description.affiliationUniv British Columbia, Neurol Div, Dept Med, Prince George, BC, Canada
dc.description.affiliationUniv British Columbia, Northern Med Program, Prince George, BC, Canada
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psiquiatria, Sao Paulo, Brazil
dc.description.sponsorshipIDBrain Canada: AARG501466
dc.description.sponsorshipIDCanadian Institutes of Health Research: 125740
dc.description.sponsorshipIDCanadian Institutes of Health Research: 13129
dc.description.sourceWeb of Science
dc.coverageNew York

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