Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease

Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease

Author Swardfager, Walter Google Scholar
Yu, Di Google Scholar
Scola, Gustavo Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Chan, Parco Google Scholar
Zou, Yi Google Scholar
Herrmann, Nathan Google Scholar
Lanctot, Krista L. Google Scholar
Ramirez, Joel Google Scholar
Gao, Fuqiang Google Scholar
Masellis, Mario Google Scholar
Swartz, Richard H. Google Scholar
Sahlas, Demetrios J. Google Scholar
Chan, Pak Cheung Google Scholar
Ojeda-Lopez, Carmen Google Scholar
Milan-Tomas, Angela Google Scholar
Pettersen, Jacqueline A. Google Scholar
Andreazza, Ana C. Google Scholar
Black, Sandra E. Google Scholar
Abstract Subcortical white matter hyperintensities (WMH), presumed to indicate small vessel ischemic vascular disease, are found commonly in elderly individuals with and without Alzheimer's disease (AD). Oxidative stress may instigate or accelerate the development of vascular disease, and oxidative stress markers are elevated in AD. Here, we assess independent relationships between three serum lipid peroxidation markers (lipid hydroperoxides [LPH], 8-isoprostane, and 4-hydroxynonenal) and the presence of extensive subcortical WMH and/or AD. Patients were recruited from memory and stroke prevention clinics into four groups: minimal WMH, extensive WMH, AD with minimal WMH, and AD with extensive WMH. Extensive WMH, but not AD, was associated with higher serum concentrations of 8-isoprostane and LPH. Peripheral LPH concentrations mediated the effect of hypertension on deep, but not periventricular, WMH volumes. 4-hydroxynonenal was associated with hyperlipidemia and cerebral micro-bleeds, but not with extensive WMH or AD. We conclude that lipid peroxidation mediates hypertensive injury to the deep subcortical white matter and that peripheral blood lipid peroxidation markers indicate subcortical small vessel disease regardless of an AD diagnosis. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Small vessel disease
Cerebrovascular disease
Oxidative stress
White matter hyperintensities
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Canadian Partnership for Stroke Recovery
Canadian Institutes of Health Research
Alzheimer's Association (USA)
Brain Canada
Alzheimer's Association (US)
Brain Canada
Sunnybrook Health Sciences Centre Department of Psychiatry
Sunnybrook Research Institute
University of Toronto Department of Pharmacology Toxicology
Centre for Collaborative Drug Research
Fondation Leducq
Canadian Institutes of Health Research
Heart & Stroke Foundation Canadian Partnership for Stroke Recovery
Linda C. Campbell Foundation
Canadian Vascular Network
Ontario Brain Institute's Ontario Neurodegenerative Disease Research Initiative
Sunnybrook Health Sciences Centre Department of Medicine
Brill Chair Neurology
University of Toronto
Heart and Stroke Foundation
Ontario Brain Institute (ONDRI)
Departments of Medicine at the University of Toronto
Sunnybrook Health Sciences Centre
Brill Chair in Neurology at Sunnybrook
Grant number Brain Canada: AARG501466
Canadian Institutes of Health Research: 125740
Canadian Institutes of Health Research: 13129
Date 2017
Published in Neurobiology Of Aging. New York, v. 59, p. 91-97, 2017.
ISSN 0197-4580 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Inc
Extent 91-97
Origin http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.029
Access rights Closed access
Type Article
Web of Science ID WOS:000411446800011
URI https://repositorio.unifesp.br/handle/11600/58323

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account