Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity

Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity

Author Mick, Inge Google Scholar
Ramos, Anna C. Autor UNIFESP Google Scholar
Myers, Jim Google Scholar
Stokes, Paul R. Google Scholar
Chandrasekera, Samantha Google Scholar
Erritzoe, David Google Scholar
Mendez, Maria A. Google Scholar
Gunn, Roger N. Google Scholar
Rabiner, Eugenii A. Google Scholar
Searle, Graham E. Google Scholar
Galduroz, Jose C. F. Autor UNIFESP Google Scholar
Waldman, Adam D. Google Scholar
Bowden-Jones, Henrietta Google Scholar
Clark, Luke Google Scholar
Nutt, David J. Google Scholar
Lingford-Hughes, Anne R. Google Scholar
Abstract As a behavioural addiction, gambling disorder (GD) provides an opportunity to characterize addictive processes without the potentially confounding effects of chronic excessive drug and alcohol exposure. Impulsivity is an established precursor to such addictive behaviours, and GD is associated with greater impulsivity. There is also evidence of GABAergic dysregulation in substance addiction and in impulsivity. This study therefore investigated GABA(A) receptor availability in 15 individuals with GD and 19 healthy volunteers (HV) using [C-11]Ro15-4513, a relatively selective 5 benzodiazepine receptor PET tracer and its relationship with impulsivity. We found significantly higher [C-11]Ro15-4513 total distribution volume (V-T) in the right hippocampus in the GD group compared with HV. We found higher levels of the Negative Urgency' construct of impulsivity in GD, and these were positively associated with higher [C-11]Ro15-4513 V-T in the amygdala in the GD group; no such significant correlations were evident in the HV group. These results contrast with reduced binding of GABAergic PET ligands described previously in alcohol and opiate addiction and add to growing evidence for distinctions in the neuropharmacology between substance and behavioural addictions. These results provide the first characterization of GABA(A) receptors in GD with [C-11]Ro15-4513 PET and show greater 5 receptor availability and positive correlations with trait impulsivity. This GABAergic dysregulation is potential target for treatment.
Keywords GABA system
gambling disorder
[C-11]Ro15-4513 PET
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Medical Research Council]
National Institute for Health Research Imperial Biomedical Research Centre
Grant number Medical Research Council: MRC G1002226
CAPES: PDSE 99999.014476/2013-04
Date 2017
Published in Addiction Biology. Hoboken, v. 22, n. 6, p. 1601-1609, 2017.
ISSN 1355-6215 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 1601-1609
Origin http://dx.doi.org/10.1111/adb.12457
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000413904600011
URI https://repositorio.unifesp.br/handle/11600/58279

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