Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up

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dc.contributor.author Lunsford-Avery, Jessica R.
dc.contributor.author Brandao Goncalves, Bruno da Silva [UNIFESP]
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.contributor.author Bressan, Rodrigo A. [UNIFESP]
dc.contributor.author Gadelha, Ary [UNIFESP]
dc.contributor.author Auerbach, Randy P.
dc.contributor.author Mittal, Vijay A.
dc.date.accessioned 2020-09-01T13:21:26Z
dc.date.available 2020-09-01T13:21:26Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1016/j.schres.2017.01.051
dc.identifier.citation Schizophrenia Research. Amsterdam, v. 189, p. 37-42, 2017.
dc.identifier.issn 0920-9964
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/58253
dc.description.abstract Background: Individuals with psychotic disorders experience disruptions to both the sleep and circadian components of the sleep/wake cycle. Recent evidence has supported a role of sleep disturbances in emerging psychosis. However, less is known about how circadian rhythm disruptions may relate to psychosis symptoms and prognosis for adolescents with clinical high-risk (CHR) syndromes. The present study examines circadian rest/activity rhythms in CHR and healthy control (HC) youth to clarify the relationships among circadian rhythm disturbance, psychosis symptoms, psychosocial functioning, and the longitudinal course of illness. Methods: Thirty-four CHR and 32 HC participants were administered a baseline evaluation, which included clinical interviews, 5 days of actigraphy, and a sleep/activity diary. CHR (n = 29) participants were re-administered clinical interviews at a 1-year follow-up assessment. Results: Relative to HC, CHR youth exhibited more fragmented circadian rhythms and later onset of nocturnal rest. Circadian disturbances (fragmented rhythms, low daily activity) were associated with increased psychotic symptom severity among CHR participants at baseline. Circadian disruptions (lower daily activity, rhythms that were more fragmented and/or desynchronized with the light/dark cycle) also predicted severity of psychosis symptoms and psychosocial impairment at 1-year follow-up among CHR youth. Conclusions: Circadian rhythm disturbances may represent a potential vulnerability marker for emergence of psychosis, and thus, rest/activity rhythm stabilization has promise to inform early-identification and prevention/intervention strategies for CHR youth. Future studies with longer study designs are necessary to further examine circadian rhythms in the prodromal period and rates of conversion to psychosis among CHR teens. (C) 2017 Elsevier B.V. All rights reserved. en
dc.description.sponsorship National Institutes of Health
dc.format.extent 37-42
dc.language.iso eng
dc.publisher Elsevier Science Bv
dc.relation.ispartof Schizophrenia Research
dc.rights Acesso restrito
dc.subject Circadian rhythm en
dc.subject Actigraphy en
dc.subject Prodromal en
dc.subject Clinical high-risk en
dc.subject Psychosis en
dc.subject Schizophrenia en
dc.title Adolescents at clinical-high risk for psychosis: Circadian rhythm disturbances predict worsened prognosis at 1-year follow-up en
dc.type Artigo
dc.description.affiliation Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, 2608 Erwin Rd Suite 300, Durham, NC 27705 USA
dc.description.affiliation Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Psychiat, LINC, Program Recognit & Intervent Individuals At Risk, Sao Paulo, Brazil
dc.description.affiliation Harvard Med Sch, Dept Psychiat, Boston, MA USA
dc.description.affiliation McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA 02178 USA
dc.description.affiliation Northwestern Univ, Dept Psychol, Evanston, IL USA
dc.description.affiliation Northwestern Univ, Dept Psychiat, Evanston, IL USA
dc.description.affiliation Northwestern Univ, Dept Med Sociol Sci, Evanston, IL USA
dc.description.affiliation Northwestern Univ, Inst Policy Res, Evanston, IL USA
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psychiat, LINC, Program Recognit & Intervent Individuals At Risk, Sao Paulo, Brazil
dc.description.sponsorshipID National Institutes of Health: RO1-MH-094650
dc.description.sponsorshipID National Institutes of Health: R21/R33-MH-103231
dc.description.sponsorshipID National Institutes of Health: K23-MH-108704
dc.identifier.doi 10.1016/j.schres.2017.01.051
dc.description.source Web of Science
dc.identifier.wos WOS:000416392400007
dc.coverage Amsterdam
dc.citation.volume 189



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