Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses

Show simple item record Storm, Johan F. Boly, Melanie Casali, Adenauer G. [UNIFESP] Massimini, Marcello Olcese, Umberto Pennartz, Cyriel M. A. Wilke, Melanie 2020-09-01T13:21:17Z 2020-09-01T13:21:17Z 2017
dc.identifier.citation Journal Of Neuroscience. Washington, v. 37, n. 45, p. 10882-10893, 2017.
dc.identifier.issn 0270-6474
dc.description.abstract How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness. en
dc.description.sponsorship European Union's Horizon 2020 Research and Innovation Programme
dc.description.sponsorship Hermann and Lilly Schilling Foundation
dc.description.sponsorship German Research Foundation
dc.description.sponsorship Center for Nanoscale Microscopy and Molecular Physiology of the Brain
dc.description.sponsorship National Institutes of Health/National Institute of Neurological Disorders and Stroke
dc.description.sponsorship Sao Paulo Research Foundation
dc.description.sponsorship James S. McDonnell Foundation Scholar Award
dc.description.sponsorship EU Grant H2020-FETOPEN
dc.description.sponsorship Canadian Institute for Advanced Research
dc.description.sponsorship Azrieli Program in Brain, Mind and Consciousness
dc.description.sponsorship FLAG-ERA JTC project CANON
dc.description.sponsorship Norwegian Research Council
dc.description.sponsorship Netherlands Organization for Scientific Research
dc.format.extent 10882-10893
dc.language.iso eng
dc.publisher Soc Neuroscience
dc.relation.ispartof Journal Of Neuroscience
dc.rights Acesso aberto
dc.subject brain complexity en
dc.subject consciousness en
dc.subject content-specific NCC en
dc.subject functional connectivity en
dc.subject neural correlates of consciousness en
dc.subject no-report paradigm en
dc.subject Perturbational Complexity Index en
dc.subject unresponsive wakefulness en
dc.subject vegetative state en
dc.title Consciousness Regained: Disentangling Mechanisms, Brain Systems, and Behavioral Responses en
dc.type Artigo
dc.description.affiliation Univ Oslo, Inst Basal Med Sci, Div Physiol, Dept Mol Med, POB 1103 Blindern, N-0317 Oslo, Norway
dc.description.affiliation Univ Wisconsin, Dept Neurol, Madison, WI 53705 USA
dc.description.affiliation Univ Wisconsin, Dept Psychiat, Madison, WI 53719 USA
dc.description.affiliation Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliation Univ Milan, Dept Biomed & Clin Sci Luigi Sacco, I-20157 Milan, Italy
dc.description.affiliation Fdn Don Carlo Gnocchi ONLUS, Ist Ricovero & Cura Carattere Sci, I-20162 Milan, Italy
dc.description.affiliation Univ Amsterdam, Swammerdam Inst Life Sci, Cognit & Syst Neurosci Grp, NL-1098 XH Amsterdam, Netherlands
dc.description.affiliation Univ Amsterdam, Res Prior Program Brain & Cognit, NL-1098 XH Amsterdam, Netherlands
dc.description.affiliation Univ Med Goettingen, Dept Cognit Neurol, D-37075 Gottingen, Germany
dc.description.affiliation Leibniz Inst Primate Res, German Primate Ctr, D-37077 Gottingen, Germany
dc.description.affiliation Leibniz Sci Campus Primate Cognit, D-37077 Gottingen, Germany
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Inst Sci & Technol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipID European Union's Horizon 2020 Research and Innovation Programme: 720270
dc.description.sponsorshipID German Research Foundation: WI 4046/1-1
dc.description.sponsorshipID National Institutes of Health/National Institute of Neurological Disorders and Stroke: 1R03NS096379
dc.description.sponsorshipID FAPESP: 2016/08263-9
dc.description.sponsorshipID EU Grant H2020-FETOPEN: RIA 686764
dc.identifier.file WOS000414662100014.pdf
dc.identifier.doi 10.1523/JNEUROSCI.1838-17.2017
dc.description.source Web of Science
dc.identifier.wos WOS:000414662100014
dc.coverage Washington
dc.citation.volume 37
dc.citation.issue 45


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