BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative

BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative

Author Mansur, R. B. Google Scholar
Brietzke, E. Autor UNIFESP Google Scholar
McIntyre, R. S. Google Scholar
Cao, B. Google Scholar
Lee, Y. Google Scholar
Japiassu, L. Google Scholar
Chen, K. Google Scholar
Lu, R. Google Scholar
Lu, W. Google Scholar
Li, T. Google Scholar
Xu, G. Google Scholar
Lin, K. Google Scholar
Abstract Objective: To compare brain-derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures. Method: Sixty-seven bipolar offspring and 45 HCs were included (ages 8-28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme-linked immunosorbent assay. Multivariate and univariate analyses of covariance were conducted. Results: Significantly higher BDNF levels were observed among bipolar offspring, relative to HCs (P > 0.025). Offspring status moderated the association between BDNF and BMI (F-1=4.636, P = 0.034). After adjustment for relevant covariates, there was a trend for a significant interaction of group and BDNF on neuroimaging parameters (Wilks'lambda F-56,F-94=1.463, P = 0.052), with significant effects on cerebellar white matter and superior and middle frontal regions. Brain volume and BDNF were positively correlated among HCs and negatively correlated among bipolar offspring. Interactions between BDNF and BMI on brain volumes were non-significant among HCs (Wilks' lambda F-28,F-2=2.229, P = 0.357), but significant among bipolar offspring (Wilks'lambda F-28,F-12=2.899, P = 0.028). Conclusion: Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis.
Keywords bipolar disorder
mood disorders
risk factors
obesity
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor National Key R&D Program of China]
National Natural Science Foundation of China (NSFC)
Grant number National Key R&D Program of China: 2016YFC1306702
National Natural Science Foundation of China (NSFC): 81471375
National Natural Science Foundation of China (NSFC): 81671347
Date 2017
Published in Acta Psychiatrica Scandinavica. Hoboken, v. 136, n. 6, p. 607-614, 2017.
ISSN 0001-690X (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 607-614
Origin http://dx.doi.org/10.1111/acps.12822
Access rights Closed access
Type Article
Web of Science ID WOS:000414594900008
URI https://repositorio.unifesp.br/handle/11600/58141

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