Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats

Hyperoxaluria in a Model of Mini-Gastric Bypass Surgery in Rats

Author Ormanji, Milene S. Autor UNIFESP Google Scholar
Korkes, Fernando Autor UNIFESP Google Scholar
Meca, Renata Autor UNIFESP Google Scholar
Ishiy, Crysthiane S. R. A. Autor UNIFESP Google Scholar
Finotti, Gustavo H. C. Autor UNIFESP Google Scholar
Ferraz, Renato R. N. Autor UNIFESP Google Scholar
Heilberg, Ita P. Autor UNIFESP Google Scholar
Abstract Bariatric surgery is associated with hyperoxaluria hence predisposing to nephrolithiasis. The present study aimed to investigate the underlying mechanisms contributing to increased urinary oxalate in a mini-gastric bypass (MGB) surgery model in rats under different dietary conditions. The expression of intestinal oxalate transporters was also evaluated. Male rats underwent MGB (n = 21) or Sham procedure (n = 21) and after recovery were fed a standard or high-fat diet with or without oxalate for 8 weeks. Stool and urine were collected before surgery (baseline) and at the end of protocol (final), when intestinal fragments were harvested for expression of Slc26a3 and Slc26a6 oxalate transporters. MGB groups fed with fat, irrespective of oxalate supplementation, presented steatorrhea. In MGB animals fed with fat and oxalate (Fat + Ox), final values of urinary oxalate and calcium oxalate supersaturation risk were markedly and significantly increased versus baseline or Sham animals under the same diet, as well as MGB groups under other diets. Slc26a3 was decreased in biliopancreatic limbs of MGB rats, probably reflecting a physiological adaptation to the restriction of food passage. Slc26a6 was not altered in any harvested intestinal fragment. A high-fat and oxalate diet induced hyperoxaluria and elevation in calcium oxalate supersaturation risk in a MGB rat model. The presence of fat malabsorption and increased dietary oxalate absorption, but not modifications of Slc26a3 and Slc26a6 oxalate transporters, accounted for these findings, suggesting that bariatric patients may benefit from a low-fat and low-oxalate diet.
Keywords Bariatric surgery
Calcium oxalate
Hyperoxaluria
Nephrolithiasis
Steatorrhea
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2010/52180-4]
Date 2017
Published in Obesity Surgery. New York, v. 27, n. 12, p. 3202-3208, 2017.
ISSN 0960-8923 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 3202-3208
Origin http://dx.doi.org/10.1007/s11695-017-2725-3
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000416562700017
URI https://repositorio.unifesp.br/handle/11600/58119

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