• RI - Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
    • português (Brasil)
    • English
    • español
  • Sobre
    • RI Unifesp
    • Documentos
    • Tutoriais
    • Perguntas frequentes
    • Atendimento
    • Equipe
  • English 
    • português (Brasil)
    • English
    • español
    • português (Brasil)
    • English
    • español
  • Login
View Item 
  •   DSpace Home
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF)
  • ICAQF - Artigos
  • View Item
  •   DSpace Home
  • Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF)
  • ICAQF - Artigos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Chitosan-based mucoadhesive gel for oral mucosal toluidine blue O delivery: The influence of a non-ionic surfactant

Thumbnail
Date
2017
Author
Junqueira Garcia, Maria Teresa [UNIFESP]
Freitas, Cristhiane de Paula
Graciano, Thierllen Barroso
Coutinho, Tatielle Soares
Cressoni, Camila Beatriz
de Lima Pereira, Sanivia Aparecida
Shimano, Marcos Massao
Type
Artigo
ISSN
1572-1000
Is part of
Photodiagnosis And Photodynamic Therapy
DOI
10.1016/j.pdpdt.2017.08.009
Metadata
Show full item record
Abstract
Photodynamic therapy (PDT) has been successfully employed in the treatment of oral cancer. Toluidine blue 0 (TBO) is a photosensitizer (PS) that has exhibited remarkable photocytotoxicity in a variety of tumour cells; however, its physicochemical properties, as well as the physicochemical properties of oral mucosa, prevent the drug from reaching the target site at a therapeutic concentration. The aim of this study was to evaluate the influence of Tween 80 (R) (TW), which has shown potential as a penetration enhancer, on the mucosal retention of TBO for the PDT of oral cancer. 4% Chitosan-based mucoadhesive gels (CH gels) containing or not 5%TW were prepared (both containing 1%TBO), and their physicochemical properties (pH, rheology and mucoadhesion), TBO in vitro release profiles and TBO in vitro mucosal retention were evaluated. In vivo mucosal penetration studies of TBO followed by laser exposition were also carried out. The results showed that 4%CH gels containing 5%TW and 1%TBO have adequate mucoadhesive and Theological properties for oral mucosa use, although they present a slightly acid pH. TBO release studies showed that TW reduces TBO release, but it prolongs TBO release and increases TBO retention in the mucosa. In vivo studies showed that 4%CH gels containing 5%TW and 1%TBO cause an increase in the number of apoptotic cell, after laser exposition. In summary, 4%CH gels containing 5%TW may be a promising vehicle to optimize the penetration of TBO in oral mucosa and to improve the PDT response for the treatment of oral cancer.
Citation
Photodiagnosis And Photodynamic Therapy. Amsterdam, v. 20, p. 48-54, 2017.
Keywords
Chitosan-based mucoadhesive gel
Oral cancer
Photodynamic therapy
Toluidine blue O
Tween 80 (R)
Polyoxyethylene (20) sorbitan monooleate
Chemical penetration enhancer
Sponsorship
School of Pharmacy at the University of Uberaba ('UNIUBE')
Programa Institutional de Bolsas de Iniciacao Cientifica (PIBIC) at UNIUBE
PIBIC/UNIUBE fellowship
CNPq/UNIUBE fellowship
URI
https://repositorio.unifesp.br/handle/11600/58066
Collections
  • ICAQF - Artigos [1140]

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy Submit DateThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Submit Date

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2016  DuraSpace
Contact Us
Theme by 
Atmire NV