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dc.contributor.authorMaurya, Pawan Kumar [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorRizzo, Lucas B. [UNIFESP]
dc.contributor.authorRios, Adiel C. [UNIFESP]
dc.contributor.authorNunes, Sandra O. V.
dc.contributor.authorBarbosa, Decio Sabbatini
dc.contributor.authorSethi, Sumit [UNIFESP]
dc.contributor.authorZeni, Maiara [UNIFESP]
dc.contributor.authorMansur, Rodrigo B.
dc.contributor.authorMaes, Michael
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.identifier.citationProgress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 65, p. -, 2016.
dc.description.abstractMajor depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age-associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor kappa B, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising. (C) 2015 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipScience without Borders-Level A
dc.description.sponsorshipcoordination of Improvement of Higher Education Personnel (CAPES)
dc.description.sponsorshipNational Counsel of Technological and Scientific Development (CNPq), Brazil
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress In Neuro-Psychopharmacology & Biological Psychiatry
dc.rightsAcesso restrito
dc.subjectOxidative stressen
dc.subjectAccelerated agingen
dc.subjectMajor depressive disorderen
dc.subjectClinical implicationsen
dc.titleThe role of oxidative and nitrosative stress in accelerated aging and major depressive disorderen
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.affiliationAmity Univ Uttar Pradesh, Amity Inst Biotechnol, Noida, India
dc.description.affiliationUniv Tubingen, Dept Psychiat, Clin Psychiat & Psychotherapy, Tubingen, Germany
dc.description.affiliationUniv Estadual Londrina, Grad Program Hlth Sci, Londrina, PR, Brazil
dc.description.affiliationUniv Toronto, MDPU, UHN, Toronto, ON, Canada
dc.description.affiliationChulalongkorn Univ, Dept Psychiat, Bangkok, Thailand
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil
dc.description.sourceWeb of Science

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