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dc.contributor.authorFerreira, Vanessa Meira [UNIFESP]
dc.contributor.authorPassos, Clevia Santos [UNIFESP]
dc.contributor.authorMaquigussa, Edgar [UNIFESP]
dc.contributor.authorPontes, Roberto Braz [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorBoim, Mirian Aparecida [UNIFESP]
dc.date.accessioned2020-08-21T17:00:22Z
dc.date.available2020-08-21T17:00:22Z
dc.date.issued2016
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0150096
dc.identifier.citationPlos One. San Francisco, v. 11, n. 2, p. -, 2016.
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57959
dc.description.abstractPregnancy is characterized by maternal systemic and intrarenal vasodilation, leading to increases in the renal plasma flow (RPF) and glomerular filtration rate (GFR). These responses are mainly mediated by nitric oxide (NO) and relaxin. The impact of cigarette smoking on the maternal adaptations to pregnancy is unclear. Here we evaluated the effects of chronic exposure to nicotine on systemic and intrarenal parameters in virgin (V) and 14-day pregnant (P) Wistar rats. V and P groups received saline or nicotine (6 mg.kg(-1).day(-1)) respectively, via osmotic minipumps for 28 days, starting 14 days before pregnancy induction. Nicotine induced a 10% increase in blood pressure in the V group and minimized the characteristic pregnancy-induced hypotension. Renal sympathetic nerve activity (rSNA) and baroreflex sensitivity were impaired by nicotine mainly in the P group, indicating that the effect of nicotine on blood pressure was not mediated by nervous system stimulation. Nicotine had no effect on GFR in the V rats but reduced GFR of the P group by 30%. Renal expression of sodium and water transporters was downregulated by nicotine, resulting in increased fractional sodium excretion mainly in the P group, suggesting that nicotine compromised the sodium and water retention required for normal gestation. There was a reduction in the expression of inducible NO synthase (iNOS) in both the kidney tissue and renal artery, as well as in the expression of the relaxin receptor (LGR7). These results clearly show that nicotine induced deleterious effects in both virgin and pregnant animals, and abolished the maternal capacity to adapt to pregnancy.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.format.extent-
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsAcesso aberto
dc.titleChronic Nicotine Exposure Abolishes Maternal Systemic and Renal Adaptations to Pregnancy in Ratsen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, Cardiovasc Div, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2010/11953-0
dc.description.sponsorshipIDFAPESP: 2010/098490
dc.identifier.fileWOS000371175700054.pdf
dc.identifier.doi10.1371/journal.pone.0150096
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000371175700054
dc.coverageSan Francisco
dc.citation.volume11
dc.citation.issue2


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