beta-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios

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dc.contributor.author Ribeiro, Camilla M. [UNIFESP]
dc.contributor.author Silva, Erick J. R. [UNIFESP]
dc.contributor.author Hinton, Barry T.
dc.contributor.author Avellar, Maria Christina W. [UNIFESP]
dc.date.accessioned 2020-08-21T17:00:17Z
dc.date.available 2020-08-21T17:00:17Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.4103/1008-682X.168791
dc.identifier.citation Asian Journal Of Andrology. Mumbai, v. 18, n. 2, p. 323-328, 2016.
dc.identifier.issn 1008-682X
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57927
dc.description.abstract beta-defensins are components of host defense, with antimicrobial and pleiotropic immuno-modulatory properties. Research over the last 15 years has demonstrated abundant expression of a variety of -defensins in the postnatal epididymis of different species. A gradient of region- and cell-specific expression of these proteins is observed in the epithelium of the postnatal epididymis. Their secretion into the luminal fluid and binding to spermatozoa as they travel along the epididymis has suggested their involvement in reproduction-specific tasks. Therefore, continuous attention has been given to various -defensins for their role in sperm function and fertility. Although -defensins are largely dependent on androgens, the underlying mechanisms regulating their expression and function in the epididymis are not well understood. Recent investigation has pointed out to a new and interesting scenario where -defensins emerge with a different expression pattern in the Wolffian duct, the embryonic precursor of the epididymis, as opposed to the adult epididymis, thereby redefining the concept concerning the multifunctional roles of -defensins in the developing epididymis. In this review, we summarize some current views of -defensins in the epididymis highlighting our most recent data and speculations on their role in the developing epididymis during the prenatal-to-postnatal transition, bringing attention to the many unanswered questions in this research area that may contribute to a better understanding of epididymal biology and male fertility. en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorship CNPq/Science Without Borders
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship National Institutes of Health Eunice Kennedy Shriver NICHD
dc.format.extent 323-328
dc.language.iso eng
dc.publisher Medknow Publications & Media Pvt Ltd
dc.relation.ispartof Asian Journal Of Andrology
dc.rights Acesso aberto
dc.subject androgens en
dc.subject embryogenesis en
dc.subject epididymis en
dc.subject organogenesis en
dc.subject beta-defensins en
dc.title beta-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, Sao Paulo, Brazil
dc.description.affiliation Univ Virginia, Sch Med, Dept Cell Biol, Charlottesville, VA 22908 USA
dc.description.affiliation Univ Estadual Paulista, Dept Pharmacol, Inst Biosci Botucatu, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, Sao Paulo, Brazil
dc.description.sponsorshipID CNPq: 480452/2008-3
dc.description.sponsorshipID CNPq: 455450/2014-5
dc.description.sponsorshipID CNPq: 308349/2010-5
dc.description.sponsorshipID CNPq/Science Without Borders: PVE401932/2013-3
dc.description.sponsorshipID CNPq/Science Without Borders: 167292-2013-7
dc.description.sponsorshipID CNPq/Science Without Borders: 401718/2012-3
dc.description.sponsorshipID CAPES: 02921/09-2
dc.description.sponsorshipID FAPESP: 2010/52711-0
dc.description.sponsorshipID FAPESP: 2009/14649-3
dc.description.sponsorshipID National Institutes of Health Eunice Kennedy Shriver NICHD: HD069654
dc.description.sponsorshipID National Institutes of Health Eunice Kennedy Shriver NICHD: HD068365
dc.identifier.file WOS000370293900033.pdf
dc.identifier.doi 10.4103/1008-682X.168791
dc.description.source Web of Science
dc.identifier.wos WOS:000370293900033
dc.coverage Mumbai
dc.citation.volume 18
dc.citation.issue 2



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