Adipokines, metabolic dysfunction and illness course in bipolar disorder

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dc.contributor.author Mansur, Rodrigo B. [UNIFESP]
dc.contributor.author Rizzo, Lucas B. [UNIFESP]
dc.contributor.author Santos, Camila M. [UNIFESP]
dc.contributor.author Asevedo, Elson [UNIFESP]
dc.contributor.author Cunha, Graccielle R. [UNIFESP]
dc.contributor.author Noto, Mariane N. [UNIFESP]
dc.contributor.author Pedrini, Mariana [UNIFESP]
dc.contributor.author Zeni, Maiara [UNIFESP]
dc.contributor.author Cordeiro, Quirino
dc.contributor.author McIntyre, Roger S.
dc.contributor.author Brietzke, Elisa [UNIFESP]
dc.date.accessioned 2020-08-21T17:00:16Z
dc.date.available 2020-08-21T17:00:16Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1016/j.jpsychires.2015.12.003
dc.identifier.citation Journal Of Psychiatric Research. Oxford, v. 74, p. 63-69, 2016.
dc.identifier.issn 0022-3956
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/57922
dc.description.abstract Replicated evidence indicates that individuals with BD are differentially affected by metabolic comorbidities and that its occurrence is a critical mediator and/or moderator of BD outcomes. This study aimed to explore the role of adipokines on bipolar disorder (BD) course and its relationship with metabolic comorbidities (i.e. type 2 diabetes mellitus, obesity). We measured plasma levels of adiponectin and leptin, as well as anthropometric and metabolic parameters of 59 patients with BD and 28 healthy volunteers. Our results showed that, in female participants, adiponectin was lower in individuals with BD, relative to healthy controls (p = 0.017). In the BD population, adiponectin levels were correlated with fasting glucose (r = -0.291, p = 0.047), fasting insulin (r = -0.332, p = 0.023), C-peptide (r = 0.040, p = 0.040), homeostatic model assessment-insulin resistance (r = -0.411, p = 0.004), HDL (r = 0.508, p < 0.001), VLDL (r = -0395, p = 0.005) and triglycerides (r = -0.310, p = 0.030). After adjustment for age, gender and BMI, individuals with BD and low adiponectin levels (i.e. < 7.5 mu g/ml), had a higher number of mood episodes (p < 0.001), lower number of psychiatric hospitalizations (p = 0.007), higher depressive symptoms (p < 0.001) and lower levels of functioning (p = 0.020). In conclusion, adiponectin levels, either directly or as a proxy of metabolic dysfunction, is independently associated with an un-favorable course of illness in BD. (C) 2015 Elsevier Ltd. All rights reserved. en
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.format.extent 63-69
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.relation.ispartof Journal Of Psychiatric Research
dc.rights Acesso restrito
dc.subject Bipolar disorder en
dc.subject Metabolism en
dc.subject Leptin en
dc.subject Adiponectin en
dc.title Adipokines, metabolic dysfunction and illness course in bipolar disorder en
dc.type Artigo
dc.description.affiliation Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliation Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit MDPU, Toronto, ON, Canada
dc.description.affiliation Univ Tubingen, Clin Psychiat & Psychotherapy, Dept Psychiat, Tubingen, Germany
dc.description.affiliation Vila Maria Outpatient Clin, Sao Paulo, Brazil
dc.description.affiliation Irmandade Santa Casa Misericordia Sao Paulo ISCMS, Dept Psychiat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LINC, Dept Psychiat, Sao Paulo, Brazil
dc.identifier.doi 10.1016/j.jpsychires.2015.12.003
dc.description.source Web of Science
dc.identifier.wos WOS:000370905000011
dc.coverage Oxford
dc.citation.volume 74



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