The burden of serious human fungal infections in Brazil

The burden of serious human fungal infections in Brazil

Author Giacomazzi, Juliana Google Scholar
Baethgen, Ludmila Google Scholar
Carneiro, Lilian C. Google Scholar
Millington, Maria Adelaide Google Scholar
Denning, David W. Google Scholar
Colombo, Arnaldo L. Autor UNIFESP Google Scholar
Pasqualotto, Alessandro C. Google Scholar
Abstract In Brazil, human fungal infections are prevalent, however, these conditions are not officially reportable diseases. To estimate the burden of serious fungal diseases in 1 year in Brazil, based on available data and published literature. Historical official data from fungal diseases were collected from Brazilian Unified Health System Informatics Department (DATASUS). For fungal diseases for which no official data were available, assumptions of frequencies were made by estimating based on published literature. The incidence (/1000) of hospital admissions for coccidioidomycosis was 7.12; for histoplasmosis, 2.19; and for paracoccidioidomycosis, 7.99. The estimated number of cryptococcal meningoencephalitis cases was 6832. Also, there were 4115 cases of Pneumocystis pneumonia in AIDS patients per year, 1 010 465 aspergillosis and 2 981 416 cases of serious Candida infections, including invasive and non-invasive diseases. In this study, we demonstrate that more than 3.8 million individuals in Brazil may be suffering from serious fungal infections, mostly patients with malignant cancers, transplant recipients, asthma, previous tuberculosis, HIV infection and those living in endemic areas for truly pathogenic fungi. The scientific community and the governmental agencies should work in close collaboration in order to reduce the burden of such complex, difficult-to-diagnose and hard to treat diseases.
Keywords Fungal infections
Brazilian fungal burden
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2016
Published in Mycoses. Hoboken, v. 59, n. 3, p. 145-150, 2016.
ISSN 0933-7407 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 145-150
Access rights Closed access
Type Article
Web of Science ID WOS:000371432000002

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