Basal neutrophil function in human aging: Implications in endothelial cell adhesion

Basal neutrophil function in human aging: Implications in endothelial cell adhesion

Author Nogueira-Neto, Joes Google Scholar
Cardoso, Andre S. C. Google Scholar
Monteiro, Hugo P. Google Scholar
Fonseca, Fernando L. A. Google Scholar
Ramos, Luiz Roberto Google Scholar
Junqueira, Virginia B. C. Google Scholar
Simon, Karin A. Google Scholar
Abstract Much attention has been drawn to the pro-inflammatory condition that accompanies aging. This study compared parameters from non-stimulated neutrophils, obtained from young (18-30 years old [y.o.]) and elderly (65-80 y.o.) human volunteers. Measured as an inflammatory marker, plasmatic concentration of hs-CRP was found higher in elderly individuals. Non-stimulated neutrophil production of ROS and NO was, respectively, 38 and 29% higher for the aged group. From the adhesion molecules evaluated, only CD11b expression was elevated in neutrophils from the aged group, whereas no differences were found for CD11a, CD18, or CD62. A 69% higher non-stimulated in vitro neutrophil/endothelial cell adhesion was observed for neutrophils isolated from elderly donors. Our results suggest that with aging, neutrophils may be constitutively producing more reactive species in closer proximity to endothelial cells of vessel walls, which may both contribute to vascular damage and reflect a neutrophil intracellular disrupted redox balance, altering neutrophil function in aging.
Keywords aging
cell function
endothelial implications
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Brazilian Federal Government Funding Agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number CAPES: AUX-PRODOC-106/2005
Date 2016
Published in Cell Biology International. Hoboken, v. 40, n. 7, p. 796-802, 2016.
ISSN 1065-6995 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 796-802
Access rights Closed access
Type Article
Web of Science ID WOS:000377892100008

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