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dc.contributor.authorMarques, E. S.
dc.contributor.authorFroder, J. G.
dc.contributor.authorCarvalho, J. C. T.
dc.contributor.authorRosa, P. C. P.
dc.contributor.authorPerazzo, F. F. [UNIFESP]
dc.contributor.authorMaistro, E. L.
dc.identifier.citationFood And Chemical Toxicology. Oxford, v. 93, p. 13-19, 2016.
dc.description.abstractE. oleracea is a tropical plant from the Amazon region, with its fruit used for food, and traditionally, as an antioxidant, anti-inflammatory, hypocholesterolemic, for atherosclerotic disease, and has anticancer properties. The oil of the fruit has antidiarrheic, anti-inflammatory and antinociceptive activities, but without genotoxicity evaluation. Therefore, the aim of this study was to evaluate the genotoxic potential of E. oleracea fruit oil (EOO), in rat cells. Male Wistar rats were treated with EOO by gavage at doses of 30, 100 and 300 mg/kg, for 14 days, within a 24 h interval. The DNA damage in the leukocytes, liver, bone marrow and testicular cells, was assessed by the comet assay, and the clastogenic/aneugenic effects in the bone marrow cells, by the micronucleus test. Our phytochemicals characterization of the EOO showed the presence of vanillic, palmitic, gamma-linolenic, linoleic, oleic, cinnamic, caffeic, protocatechuic, ferulic, syringic acids, and flavonoids quercetin and kaempferol rutinoside as the main constituents. Both cytogenetic tests performed showed that EOO presented no significant genotoxic effects in the analyzed cells, at the three tested doses. These results indicate that, under our experimental conditions, E. oleracea fruit oil did not reveal genetic toxicity in rat cells. (C) 2016 Published by Elsevier Ltd.en
dc.description.sponsorshipFAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofFood And Chemical Toxicology
dc.rightsAcesso restrito
dc.subjectEuterpe oleraceaen
dc.subjectAcai oilen
dc.subjectPhytochemical of acaien
dc.subjectComet assayen
dc.subjectMicronucleus testen
dc.titleEvaluation of the genotoxicity of Euterpe oleraceae Mart. (Arecaceae) fruit oil (acai), in mammalian cells in vivoen
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biociencias, Programa Posgrado Biol Geral & Aplicada, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Amapa, Colegiado Farm, Lab Pesquisa Farmacos, Ctr Ciencias Biol & Saude, Macapa, AP, Brazil
dc.description.affiliationUniv Estadual Campinas UNICAMP, Fac Ciencias Med, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Ciencias Exatas & Terra, Diadema, SP, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Filosofia & Ciencias, Dept Fonoaudiol, Av Hyg Muzzi Filho 737,Caixa Postal 18, BR-17525900 Marilia, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Ciencias Exatas & Terra, Diadema, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2012/17241-8
dc.description.sourceWeb of Science

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