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dc.contributor.authorOliveira, Rudolf K. F. [UNIFESP]
dc.contributor.authorWaxman, Aaron B.
dc.contributor.authorAgarwal, Manyoo
dc.contributor.authorEslam, Roza Badr
dc.contributor.authorSystrom, David M.
dc.identifier.citationEuropean Respiratory Journal. Sheffield, v. 48, n. 1, p. 158-167, 2016.
dc.description.abstractAssessment of cardiac function during exercise can be technically demanding, making the recovery period a potentially attractive diagnostic window. However, the validity of this approach for exercise pulmonary haemodynamics has not been validated. The present study, therefore, evaluated directly measured pulmonary haemodynamics during 2-min recovery after maximum invasive cardiopulmonary exercise testing in patients evaluated for unexplained exertional intolerance. Based on peak exercise criteria, patients with exercise pulmonary hypertension (ePHen
dc.description.abstractn=36), exercise pulmonary venous hypertension (ePVHen
dc.description.abstractn=28) and age-matched controls (n=31) were analysed. By 2-min recovery, 83% (n=30) of ePH patients had a mean pulmonary artery pressure (mPAP) < 30 mmHg and 96% (n=27) of ePVH patients had a pulmonary arterial wedge pressure (PAWP) < 20 mmHg. Sensitivity of pulmonary hypertension-related haemodynamic measurements during recovery for ePH and ePVH diagnosis was <= 25%. In ePVH, pulmonary vascular compliance (PVC) returned to its resting value by 1-min recovery, while in ePH, elevated pulmonary vascular resistance (PVR) and decreased PVC persisted throughout recovery. In conclusion, we observed that mPAP and PAWP decay quickly during recovery in ePH and ePVH, compromising the sensitivity of recovery haemodynamic measurements in diagnosing pulmonary hypertension. ePH and ePVH had different PVR and PVC recovery patterns, suggesting differences in the underlying pulmonary hypertension pathophysiology.en
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development (CNPq)
dc.description.sponsorshipAustrian Science Fund (FWF), Erwin Schroedinger
dc.publisherEuropean Respiratory Soc Journals Ltd
dc.relation.ispartofEuropean Respiratory Journal
dc.rightsAcesso restrito
dc.titlePulmonary haemodynamics during recovery from maximum incremental cycling exerciseen
dc.description.affiliationBrigham & Womens Hosp, Dept Med, Pulm & Crit Care Med, Clin 3,75 Francis St, Boston, MA 02115 USA
dc.description.affiliationHarvard Med Sch, Boston, MA USA
dc.description.affiliationBrigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Med, Div Resp Dis, Sao Paulo, Brazil
dc.description.affiliationMed Univ Vienna, Dept Internal Med 2, Div Cardiol, Vienna, Austria
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Med, Div Resp Dis, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2014/12212-5
dc.description.sponsorshipIDCNPq: 232643/2014-8
dc.description.sponsorshipIDAustrian Science Fund (FWF), Erwin Schroedinger: J3522-B13
dc.description.sponsorshipIDNIH: 2R01HL060234-12A1
dc.description.sponsorshipIDNIH: U01HL125215-01
dc.description.sourceWeb of Science

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