Sleep restriction reduces the survival time and aggravates the neurological dysfunction and memory impairments in an animal model of cerebral hypoperfusion

Sleep restriction reduces the survival time and aggravates the neurological dysfunction and memory impairments in an animal model of cerebral hypoperfusion

Author Kim, Lenise Jihe Autor UNIFESP Google Scholar
Coelho, Fernando Morgadinho Autor UNIFESP Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Tedesco, Roberto Carlos Autor UNIFESP Google Scholar
Souza, Rodrigo Barbosa Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Abstract Cerebral blood flow is associated with the cerebrovascular prognosis. Sleep restriction (SR) may be a limiting factor of the prognosis after a cerebrovascular event, impairing the neurological recovery. We aimed to investigate the effects of SR on mortality rate and on behavioral and histological parameters of animals submitted to permanent cerebral hypoperfusion. Sixty male Wistar rats were distributed in 4 groups, according to the protocol of common carotid artery occlusion (CCAO) and SR: nSR+nCCAO, SR+nCCAO, nSR+CCAO, and SR+CCAO. The groups SR+nCCAO and SR+CCAO were submitted to SR during 10 days. The cerebral hypoperfusion was induced by the permanent CCAO. Neurological function and memory were assessed over 14 days of cerebral hypoperfusion. Analysis of neuropathological alterations were performed in the CA1 region of hippocampus. The mortality rate was 40% in the nSR+CCAO and SR+CCAO groups. SR significantly reduced the survival time of animals submitted to CCAO. After 7 and 14 days of cerebral hypoperfusion, 11% and 33% of the nSR+CCAO and SR+CCAO animals showed severe neurological dysfunction, respectively. A significant association between a high frequency of memory impairments with the group SR+CCAO was observed. The neuropathological alterations in CA1 region of hippocampus were similar among the groups. SR potentiates the negative effects of cerebral hypoperfusion conditions, suggesting that SR could be a factor associated with a worse prognosis after a cerebrovascular event. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Sleep restriction
Cerebral hypoperfusion
Neurological function
Memory
Mortality rate
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Sao Paulo Research Foundation (FAPESP)
CNPq
Grant number FAPESP: 2013/14420-1
FAPESP: 2014/10255-9
Date 2016
Published in Brain Research. Amsterdam, v. 1644, p. 213-221, 2016.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 213-221
Origin http://dx.doi.org/10.1016/j.brainres.2016.05.010
Access rights Closed access
Type Article
Web of Science ID WOS:000379105300023
URI https://repositorio.unifesp.br/handle/11600/57512

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