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dc.contributor.authorde Oliveira, Emerson
dc.contributor.authorda Silva Tavares, Kelly Alessandra
dc.contributor.authorVieira Gomes, Mariano Tamura
dc.contributor.authorSalzedas-Netto, Alcides Augusto [UNIFESP]
dc.contributor.authorFerreira Sartori, Marair Gracio [UNIFESP]
dc.contributor.authorCastro, Rodrigo Aquino [UNIFESP]
dc.contributor.authorFernandes, Cesar Eduardo
dc.contributor.authorBatista Castello Girao, Manoel Joao [UNIFESP]
dc.date.accessioned2020-08-04T13:39:54Z
dc.date.available2020-08-04T13:39:54Z
dc.date.issued2017
dc.identifierhttp://dx.doi.org/10.1590/S1679-45082017AO4066
dc.identifier.citationEinstein-Sao Paulo. Sao Paulo Sp, v. 15, n. 4, p. 481-485, 2017.
dc.identifier.issn1679-4508
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57176
dc.description.abstractObjective: To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression. Methods: We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood incompatibility. Hysterectomy was performed in the donor under general anesthesia, with the removal of the aorta and inferior vena cava in monobloc, and anastomosis of these vessels was made in the recipient. Results: Six experiments were performed, and on the immediate postoperative period, five animals had good reperfusion. However, on the seventh postoperative day, histological analysis showed rejection in five animals. Conclusion: The experimental model of uterine transplantation is feasible, but monitoring doses of immunosuppressants is pivotal to prevent rejection episodes.en
dc.description.abstractObjetivo: Avaliar a técnica de transplante uterino e o uso de drogas no processo de imunossupressão. Métodos: Foram incluídas 12 porcas, sendo realizada imunossupressão com doses mínimas de ciclosporina, e prova cruzada para afastar a possibilidade de incompatibilidade sanguínea. Realizou-se, na doadora, histerectomia sob anestesia geral, com a retirada, em monobloco, da aorta e da veia cava inferior, de tal forma que, na receptora, fosse possível realizar a anastomose com estes vasos. Resultados: Foram realizados seis experimentos e, no pós-operatório imediato, houve boa reperfusão em cinco animais. Entretanto, no sétimo dia de pós-operatório, as análises histológicas demonstraram rejeição em cinco deles. Conclusão: O modelo experimental de transplante uterino é factível, mas a monitorização das doses de imunossupressores é importante, a fim de impedir os episódios de rejeição.pt
dc.description.sponsorshipFundacao de Amparo a Pesquisa de Estado de Sao Paulo (FAPESP)
dc.format.extent481-485
dc.language.isoeng
dc.language.isopor
dc.publisherInst Israelita Ensino & Pesquisa Albert Einstein
dc.relation.ispartofEinstein-Sao Paulo
dc.rightsAcesso aberto
dc.subjectTransplantationen
dc.subjectUterus/transplantationen
dc.subjectInfertilityen
dc.subjectPregnancyen
dc.subjectSwineen
dc.subjectModelsen
dc.subjectanimalen
dc.subjectImmunosuppressive agentsen
dc.subjectCyclosporineen
dc.subjectTransplantept
dc.subjectÚtero/transplantept
dc.subjectInfertilidadept
dc.subjectGravidezpt
dc.subjectSuínospt
dc.subjectModelos animaispt
dc.subjectImunossupressorespt
dc.subjectCiclosporinapt
dc.titleDescription and evaluation of experimental models for uterine transplantation in pigsen
dc.title.alternativeDescrição e avaliação de modelos experimentais para transplante uterino em suínospt
dc.typeArtigo
dc.description.affiliationABC, Fac Med, Santo Andre, SP, Brazil
dc.description.affiliationHosp Israelita Albert Einstein, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Sao Paulo, SP, Brazil
dc.description.sponsorshipIDFAPESP: 2008/09441-1
dc.identifier.fileS1679-45082017000400481-en.pdf
dc.identifier.fileS1679-45082017000400481-pt.pdf
dc.identifier.scieloS1679-45082017000400481
dc.identifier.doi10.1590/S1679-45082017AO4066
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000423856800017
dc.coverageSao Paulo Sp
dc.citation.volume15
dc.citation.issue4


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