Distinct behavioral and immunoendocrine parameters during crack cocaine abstinence in women reporting childhood abuse and neglect

Distinct behavioral and immunoendocrine parameters during crack cocaine abstinence in women reporting childhood abuse and neglect

Author Levandowski, Mateus Luz Google Scholar
Viola, Thiago Wendt Google Scholar
Prado, Carine Hartmann Google Scholar
Wieck, Andrea Google Scholar
Bauer, Moises Evandro Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Grassi-Oliveira, Rodrigo Google Scholar
Abstract Aim: To assess plasma levels of cortisol and cytokines between cocaine-dependent women with and without childhood maltreatment (CM) history during cocaine detoxification treatment. Method: We assessed immunoendocrine and clinical parameters of 108 crack cocaine female users during 3 weeks of inpatient detoxification treatment, and 24 healthy women to obtain reference values. Women with (CM+, n = 53) or without (CM-, n = 55) CM history were identified answering the Childhood Trauma Questionnaire (CTQ). Blood samples and clinical assessment were collected before lunch during the first, second and third week post-treatment admission. Flow cytometry was used to assess TNF-alpha, IFN-gamma, IL-2, IL-4, IL-6, IL-10, IL-17A plasma levels and ELISA assay was used to measure plasma cortisol levels. Results: At baseline, lower Th1 and Thl 7-related cytokines levels and higher Th2 cytokines levels were observed in crack cocaine users compared with reference values. Cytokines levels of cocaine dependents gradually became closer to reference values along detoxification treatment. However, when CM+ and CM groups were compared, increased levels of IL-6, IL-4 and TNF-alpha across time were observed in CM+ group only. Additionally, a Th1/Th2 immune imbalance was observed within CM+ group, which was negatively correlated with the severity of the crack withdrawal. Finally, loading trauma exposure severity, immunoendocrine and clinical parameters in factor analysis, we identified three clusters of observed variables during detoxification: (1) systemic immunity and trauma exposure, (2) pro-inflammatory immunity and (3) behavior Conclusion: Our results suggest the existence of an immunological phenotype variant associated with CM exposure during crack cocaine detoxification of women. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Keywords Child abuse
Substance-use disorders
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Departamento de Ciência e Tecnologia da Secretaria de Ciência, Tecnologia e Insumos Estratégicos do Ministério da Saúde (Decit/SCTIE/MS)
Fundação de Amparo à Pesquisa do Estado do Estado do Rio Grande do Sul (FAPERGS)
Date 2016
Published in Drug And Alcohol Dependence. Clare, v. 167, p. 140-148, 2016.
ISSN 0376-8716 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 140-148
Origin http://dx.doi.org/10.1016/j.drugalcdep.2016.08.010
Access rights Closed access
Type Article
Web of Science ID WOS:000385325100019
URI https://repositorio.unifesp.br/handle/11600/56993

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account