Crack cocaine addiction, early life stress and accelerated cellular aging among women

Show simple item record Levandowski, Mateus Luz Tractenberg, Saulo Gantes de Azeredo, Lucas Araujo De Nardi, Tatiana Rovaris, Diego L. Bau, Claiton H. D. Rizzo, Lucas Bortolotto [UNIFESP] Maurya, Pawan Kumar [UNIFESP] Brietzke, Elisa [UNIFESP] Tyrka, Audrey R. Grassi-Oliveira, Rodrigo 2020-07-31T12:47:17Z 2020-07-31T12:47:17Z 2016
dc.identifier.citation Progress In Neuro-Psychopharmacology & Biological Psychiatry. Oxford, v. 71, p. 83-89, 2016.
dc.identifier.issn 0278-5846
dc.description.abstract Background: Early life stress (ELS) and addiction are related to age-related diseases and telomere shortening. However, the role of telomere length (TL) in crack cocaine addiction remains unknown. The purpose of this study was to investigate the TL in a sample of crack cocaine dependent-women who reported an ELS history and in a community-based sample of elderly women as a reference group for senescence. Methods: This study included treatment seeking crack cocaine dependents women (n = 127) and elderly women without a psychiatric diagnosis (ELD, n = 49). The crack cocaine sample was divided in two groups according to their Childhood Trauma Questionnaire (CTQ) scores: presence of history of childhood abuse and neglect (CRACK-ELS) and absence of ELS history (CRACK). TL was assessed by T/S ratio obtained from peripheral blood DNA using quantitative PCR assay. esults: CRACK and CRACK-ELS subjects exhibited shortened TL in comparison to the ELD group, despite their younger age. Among crack cocaine sample, CRACK-ELS group had significantly shorter telomeres than the CRACK group. Correlation analysis within crack cocaine group indicated that TL was negatively correlated with emotional abuse scores. Conclusions: These results support previous findings associating telomere shortening with both ELS and drug addiction. This study suggests new evidence of a distinct biological phenotype for drug-dependent women with ELS. The results support the biological senescence hypothesis underpinning ELS experience. (C) 2016 Elsevier Inc. All rights reserved. en
dc.format.extent 83-89
dc.language.iso eng
dc.publisher Pergamon-Elsevier Science Ltd
dc.relation.ispartof Progress In Neuro-Psychopharmacology & Biological Psychiatry
dc.rights Acesso restrito
dc.subject Aging en
dc.subject Child abuse en
dc.subject Cocaine en
dc.subject Senescence en
dc.subject Substance-related disorders en
dc.subject Telomere en
dc.title Crack cocaine addiction, early life stress and accelerated cellular aging among women en
dc.type Artigo
dc.description.affiliation Pontifical Catholic Univ Rio Grande Sul PUCRS, Biomed Res Inst IPB, DCNL, Porto Alegre, RS, Brazil
dc.description.affiliation Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, Porto Alegre, RS, Brazil
dc.description.affiliation Fed Univ Sao Paulo Unifesp, Dept Psychiat, Res Grp Behav Neurosci Bipolar Disorder, Sao Paulo, SP, Brazil
dc.description.affiliation Brown Univ, Mood Disorders Res Program, Providence, RI 02912 USA
dc.description.affiliation Brown Univ, Dept Psychiat & Human Behav, Lab Clin & Translat Neurosci, Providence, RI 02912 USA
dc.description.affiliationUnifesp Research Group in Behavioral Neuroscience of Bipolar Disorder, Department of Psychiatry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.pnpbp.2016.06.009
dc.description.source Web of Science
dc.identifier.wos WOS:000382204200010
dc.coverage Oxford
dc.citation.volume 71


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