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dc.contributor.authorRocha, Alcides [UNIFESP]
dc.contributor.authorArbex, Flavio Ferlin [UNIFESP]
dc.contributor.authorAlencar, Maria Clara Noman de [UNIFESP]
dc.contributor.authorSperandio, Priscila Abreu [UNIFESP]
dc.contributor.authorHirai, Daniel Müller [UNIFESP]
dc.contributor.authorBerton, Danilo C.
dc.contributor.authorO'Donnell, Denis E.
dc.contributor.authorNeder, Jose Alberto [UNIFESP]
dc.date.accessioned2020-07-31T12:47:09Z
dc.date.available2020-07-31T12:47:09Z
dc.date.issued2016
dc.identifierhttp://dx.doi.org/10.1016/j.ijcard.2016.09.077
dc.identifier.citationInternational Journal Of Cardiology. Clare, v. 224, p. 447-453, 2016.
dc.identifier.issn0167-5273
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56623
dc.description.abstractBackground: Exercise oscillatory ventilation (EOV) is associatedwith poor ventilatory efficiency and higher operating lung volumes in heart failure. These abnormalitiesmay be particularly deleterious to dyspnea and exercise tolerance in mechanically-limited patients, e.g. those with coexistent COPD. Methods: Ventilatory, gas exchange and sensory responses to incremental exercise were contrasted in 68 heart failure-COPD patients (12 EOV+). EOV was established by standard criteria. Results: Compared to EOV-, EOV+ had lower exercise capacity, worse ventilatory inefficiency and higher peak dyspnea scores (p < 0.05). Peak capillary PCO2 (PcCO2) was higher and end-tidal CO2 (PETCO2) was lower in EOV+. Thus, greater (i.e., more positive) P(c-ET) CO2 and dead space/tidal volume values were found in these patients compared to EOV- (p < 0.05). Ventilatory inefficiency was related to increased dead space/tidal volumein EOV+ (r = 0.74en
dc.description.abstractp < 0.01). Owing to higher operating lung volumes, inspiratory reserve volume (IRV) decreased to a greater extent in EOV+. Tidal volume oscillations consistently ceased when a "critical" IRV was reached (similar to 0.3-0.5 L)en
dc.description.abstractthereafter, PcCO2 stabilized or increased and dyspnea scores rose sharply. Exercise capacity was closely related to IRV decrements and peak dyspnea in EOV+ (r = -0.78 and 0.84, respectivelyen
dc.description.abstractp < 0.01). Conclusions: Dyspnea and exercise tolerance are negatively influenced by EOV in heart failure patients presenting with COPD as co-morbidity. Pharmacological and non-pharmacological interventions known to decrease EOV might prove particularly valuable to mitigate symptomburden and exercise intolerance in this specific heart failure group. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en
dc.format.extent447-453
dc.language.isoeng
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofInternational Journal Of Cardiology
dc.rightsAcesso restrito
dc.subjectHeart failureen
dc.subjectCOPDen
dc.subjectExertionen
dc.subjectVentilationen
dc.subjectLung mechanicsen
dc.subjectDyspneaen
dc.titlePhysiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPDen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Div Respirol, Pulm Funct & Clin Exercise Physiol Unit SEFICE, Sao Paulo, Brazil
dc.description.affiliationQueens Univ, Kingston Gen Hosp, Lab Clin Exercise Physiol, Kingston, ON, Canada
dc.description.affiliationQueens Univ, Kingston Gen Hosp, Resp Invest Unit, Kingston, ON, Canada
dc.description.affiliationUniv Fed Rio Grande do Sul, Div Respirol, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespPulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respirology, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, Brazil
dc.identifier.doi10.1016/j.ijcard.2016.09.077
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000390471300081
dc.coverageClare
dc.citation.volume224


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