Toward Quantitative Optical Coherence Tomography Angiography Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis

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Ploner, Stefan B.
Moult, Eric M.
Choi, Woojhon
Waheed, Nadia K.
Lee, Byungkun
Novais, Eduardo Amorim [UNIFESP]
Cole, Emily D.
Potsaid, Benjamin
Husvogt, Lennart
Schottenhamml, Julia
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Purpose: Currently available optical coherence tomography angiography systems provide information about blood flux but only limited information about blood flow speed. The authors develop a method for mapping the previously proposed variable interscan time analysis (VISTA) algorithm into a color display that encodes relative blood flow speed. Methods: Optical coherence tomography angiography was performed with a 1,050 nm, 400 kHz A-scan rate, swept source optical coherence tomography system using a 5 repeated B-scan protocol. Variable interscan time analysis was used to compute the optical coherence tomography angiography signal from B-scan pairs having 1.5 millisecond and 3.0 milliseconds interscan times. The resulting VISTA data were then mapped to a color space for display. Results: The authors evaluated the VISTA visualization algorithm in normal eyes (n = 2), nonproliferative diabetic retinopathy eyes (n = 6), proliferative diabetic retinopathy eyes (n = 3), geographic atrophy eyes (n = 4), and exudative age-related macular degeneration eyes (n = 2). All eyes showed blood flow speed variations, and all eyes with pathology showed abnormal blood flow speeds compared with controls. Conclusion: The authors developed a novel method for mapping VISTA into a color display, allowing visualization of relative blood flow speeds. The method was found useful, in a small case series, for visualizing blood flow speeds in a variety of ocular diseases and serves as a step toward quantitative optical coherence tomography angiography.
Retina-The Journal Of Retinal And Vitreous Diseases. Philadelphia, v. 36, n. 12, p. S118-S126, 2016.