Cortical thickness in obsessive compulsive disorder: multisite mega-analysis of 780 brain scans from six centres

Cortical thickness in obsessive compulsive disorder: multisite mega-analysis of 780 brain scans from six centres

Author Fouche, Jean-Paul Google Scholar
du Plessis, Stefan Google Scholar
Hattingh, Coenie Google Scholar
Roos, Annerine Google Scholar
Lochner, Christine Google Scholar
Soriano-Mas, Carles Google Scholar
Sato, Joao Ricardo Autor UNIFESP Google Scholar
Nakamae, Takashi Google Scholar
Nishida, Seiji Google Scholar
Kwon, Jun Soo Google Scholar
Jung, Wi Hoon Google Scholar
Mataix-Cols, David Google Scholar
Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Alonso, Pino Google Scholar
de Wit, Stella J. Google Scholar
Veltman, Dick J. Google Scholar
Stein, Dan J. Google Scholar
van den Heuvel, Odile A. Google Scholar
Abstract Background There is accumulating evidence for the role of fronto-striatal and associated circuits in obsessive -compulsive disorder (OCD) but limited and conflicting data on alterations in cortical thickness. Aims To investigate alterations in cortical thickness and subcortical volume in OCD. Method In total, 412 patients with OCD and 368 healthy adults underwent magnetic resonance imaging scans. Between group analysis of covariance of cortical thickness and subcortical volumes was performed and regression analyses undertaken. Results Significantly decreased cortical thickness was found in the OCD group compared with controls in the superior and inferior frontal, precentral, posterior cingulate, middle temporal, inferior parietal and precuneus gyri. There was also a group x age interaction in the parietal cortex, with increased thinning with age in the OCD group relative to controls. Conclusions Our findings are partially consistent with earlier work, suggesting that group differences in grey matter volume and cortical thickness could relate to the same underlying pathology of OCD. They partially support a frontostriatal model of OCD, but also suggest that limbic, temporal and parietal regions play a role in the pathophysiology of the disorder. The group x age interaction effects may be the result of altered neuroplasticity. Copyright and usage (C) The Royal College of Psychiatrists 2017.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Dutch Organization for Scientific Research (NWO)
Carlos III Health Institute
Agency for Administration of University and Research (AGAUR, Barcelona)
Ministry of Education, Culture, Sports, Science, and Technology (Japan)
Wellcome Trust
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
National Research Foundation of Korea grant - Korean government (Ministry of Education, Science, and Technology)
Grant number NWO: 912-02-050
NWO: 907-00-012
NWO: 940-37- 018
NWO: 916.86.0381
Carlos III Health Institute: PI09/01331
Carlos III Health Institute: PI10/01753
Carlos III Health Institute: PI10/01003
Carlos III Health Institute: CP10/00604
Carlos III Health Institute: PI13/01958
Carlos III Health Institute: CIBER-CB06/03/0034]
AGAUR: 2009SGR1554
Ministry of Education, Culture, Sports, Science, and Technology (Japan): 23591724
Ministry of Education, Culture, Sports, Science, and Technology (Japan): 24791223
Wellcome Trust: 064846
FAPESP: 2011/21357-9
FAPESP: 2035/04206-6
National Research Foundation of Korea grant: 2012-0005150
Date 2017
Published in British Journal Of Psychiatry. London, v. 210, n. 1, p. 67-74, 2017.
ISSN 0007-1250 (Sherpa/Romeo, impact factor)
Publisher Royal College Of Psychiatrists
Extent 67-74
Access rights Closed access
Type Article
Web of Science ID WOS:000391520600012

Show full item record


File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)




My Account