Benzodiazepines for restless legs syndrome

Benzodiazepines for restless legs syndrome

Author Carlos, Karla Autor UNIFESP Google Scholar
Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Teixeira, Camila de Masi Autor UNIFESP Google Scholar
Conti, Cristiane Google Scholar
de Oliveira, Marcio M. Google Scholar
Prado, Lucila Bizari Fernandes do Autor UNIFESP Google Scholar
Carvalho, Luciane Bizari Coin de Autor UNIFESP Google Scholar
Abstract Background Restless legs syndrome (RLS) is a common disease affecting about 5% to 15% of the population. Symptoms of RLS can be severe in a minority of and can have a major impact on sleep, mostly sleep initiation, and quality of life. Benzodiazepines are drugs that can induce and maintain sleep and, hence, intuitively are thought to be beneficial to people with RLS. Altough benzodiazepines, particularly clonazepam, are used to treat RLS symptoms, a systematic review done by the American Academy of SleepMedicine stated that benzodiazepines should not be used as a first-line treatment, although could be used as a coadjuvant therapy. Objectives To evaluate the efficacy and safety of benzodiazepine compared to placebo or other treatment for idiopathic RLS, including uncon-founded trials comparing benzodiazepines versus open control. Search methods In March 2016 we searched CENTRAL, MEDLINE, Embase and LILACS We checked the references of each study and contacted study authors to identify any additional studies. We considered studies published in any language. Selection criteria Randomised clinical trials of benzodiazepine treatment in idiopathic RLS. Data collection and analysis We did not perform data collection and analysis, since we did not include any studies, Main results We did not identify any studies that met the inclusion criteria of the review. Two cross-over studies are awaiting classification because the cross-over trials did not give data at the end of the first cross-over period. Authors' conclusions The effectiveness of benzodiazepines for RLS treatment is currently unknown.
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number CNPq: 300646/2013-5
Date 2017
Published in Cochrane Database Of Systematic Reviews. Hoboken, v. , n. 3, p. -, 2017.
ISSN 1469-493X (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000400761200021

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