REM sleep deprivation impairs muscle regeneration in rats

Nenhuma Miniatura disponível
Data
2017
Autores
Mônico-Neto, Marcos [UNIFESP]
Dattilo, Murilo [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
Lee, Kil Sun [UNIFESP]
Mello, Marco Tulio de [UNIFESP]
Tufik, Sergio [UNIFESP]
Antunes, Hanna Karen Moreira [UNIFESP]
Orientadores
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration.
Descrição
Citação
Growth Factors. Abingdon, v. 35, n. 1, p. 12-18, 2017.