Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia

Influence of serum 25-hydroxyvitamin D on the rate of pain episodes in Nigerian children with sickle cell anaemia

Author Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Oyelami, Oyeku Akibu Google Scholar
Adekile, Adekunle Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Abstract Background: In sickle cell disease (SCD), symptoms of vitamin D deficiency (VDD) and chronic pain can overlap. Aim: To examine the relationship between serum vitamin D levels and the frequency of acute pain episodes. Methods: In this cross-sectional study, serum 25-hydroxyvitamin D (25-OHD) was assayed by high-performance liquid chromatography, and its influence on the number of significant pain episodes was examined by bivariate and logistic regression analyses. Results: The mean (SD) serum 25-OHD level in 123 children with SCD (HbSS) was 105.8 (24.1) nmol/L (range 37.5-155.8). Fourteen patients (11.4%) either had a deficient (1.6%) or insufficient (9.8%) level. None had severe VDD. All the children with sub-optimal vitamin D experienced pain, as did 69.7% of those with normal vitamin D [14 (100%) vs 76 (69.7%), 95% CI 0.7-0.9, p=0.04]. The mean serum vitamin D level in the 90 patients with at least one pain episode [103.1 (25.2) nmol/L] was significantly lower than the 113.1 (19.3) nmol/L in the 33 without a pain episode (95% CI 1.3-7.8, p=0.04). The frequency of pain correlated inversely with the serum 25-OHD level. Serum levels of vitamin D (OR 1.2, 95% CI 1.3-1.7, p=0.04) and fetal haemoglobin concentration (OR 1.6, 95% CI 1.1-1.4, p=0.02) predicted significant pain episodes. Conclusion: In children with SCD, there is a possible association between depressed serum vitamin D levels and increased frequency of acute pain episodes. Vitamin D supplements should be considered in patients with low levels and frequent episodes of pain.
Keywords Children
sickle cell disease
vaso-occlusive crisis
25-hydroxyvitamin D
xmlui.dri2xhtml.METS-1.0.item-coverage Abingdon
Language English
Sponsor Brazil National Council [CNPq- 159581/2014-1]
Date 2017
Published in Paediatrics And International Child Health. Abingdon, v. 37, n. 3, p. 217-221, 2017.
ISSN 2046-9047 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 217-221
Origin http://dx.doi.org/10.1080/20469047.2017.1295012
Access rights Closed access
Type Article
Web of Science ID WOS:000404518100011
URI https://repositorio.unifesp.br/handle/11600/56260

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