Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia
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Data
2016
Autores
Fernandes Pimenta, Flavia Cristina
Alves, Mateus Feitosa
Fernandes Pimenta, Martina Bragante
Linhares Melo, Silvia Adelaide
Figueiredo de Almeida, Anna Alice
Leite, Jose Roberto [UNIFESP]
Clebia de Morais Pordeus, Liana
Formiga Melo Diniz, Margareth de Fatima
de Almeida, Reinaldo Nobrega
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The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML. Copyright (c) 2016 John Wiley & Sons, Ltd.
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Phytotherapy Research. Hoboken, v. 30, n. 4, p. 613-617, 2016.