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dc.contributor.authorFernandes Pimenta, Flavia Cristina
dc.contributor.authorAlves, Mateus Feitosa
dc.contributor.authorFernandes Pimenta, Martina Bragante
dc.contributor.authorLinhares Melo, Silvia Adelaide
dc.contributor.authorFigueiredo de Almeida, Anna Alice
dc.contributor.authorLeite, Jose Roberto [UNIFESP]
dc.contributor.authorClebia de Morais Pordeus, Liana
dc.contributor.authorFormiga Melo Diniz, Margareth de Fatima
dc.contributor.authorde Almeida, Reinaldo Nobrega
dc.date.accessioned2020-07-22T13:23:16Z
dc.date.available2020-07-22T13:23:16Z
dc.date.issued2016
dc.identifierhttp://dx.doi.org/10.1002/ptr.5566
dc.identifier.citationPhytotherapy Research. Hoboken, v. 30, n. 4, p. 613-617, 2016.
dc.identifier.issn0951-418X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/56143
dc.description.abstractThe bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML. Copyright (c) 2016 John Wiley & Sons, Ltd.en
dc.description.sponsorshipCNPq
dc.format.extent613-617
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofPhytotherapy Research
dc.rightsAcesso restrito
dc.subjectchronic myeloid leukemiaen
dc.subjectanxietyen
dc.subjectCitrus aurantium L.en
dc.subjectessential oilen
dc.subjectvia inhalationen
dc.titleAnxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemiaen
dc.typeArtigo
dc.description.affiliationUniv Fed Paraiba, Dept Med, Med Sci Ctr, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Postgrad Program Bioact Nat & Synthet Prod, Ctr Hlth Sci, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Ctr Exact & Nat Sci, Grad Program Decis Models & Hlth, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Ctr Hlth Sci, Dept Speech Therapy, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Paraiba, Dept Pharmaceut Sci, Ctr Hlth Sci, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Paraiba, Dept Physiol & Pathol, Ctr Hlth Sci, BR-58059900 Joao Pessoa, Paraiba, Brazil
dc.description.affiliationFac Med New Hope, Med Acad, Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil
dc.identifier.doi10.1002/ptr.5566
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000373993500010
dc.coverageHoboken
dc.citation.volume30
dc.citation.issue4


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