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dc.contributor.authorPassos-Castilho, Ana Maria [UNIFESP]
dc.contributor.authorSena, Anne de [UNIFESP]
dc.contributor.authorDomingues, Ana Lucia Coutinho
dc.contributor.authorLopes-Neto, Edmundo Pessoa
dc.contributor.authorMedeiros, Tiberio Batista
dc.contributor.authorGranato, Celso Francisco Hernandez [UNIFESP]
dc.contributor.authorFerraz, Maria Lucia [UNIFESP]
dc.date.accessioned2020-07-22T13:22:55Z
dc.date.available2020-07-22T13:22:55Z
dc.date.issued2016
dc.identifierhttp://dx.doi.org/10.1016/j.bjid.2016.03.001
dc.identifier.citationBrazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 20, n. 3, p. 262-266, 2016.
dc.identifier.issn1413-8670
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55945
dc.description.abstractBackground: Hepatitis E virus (HEV) can cause chronic infection with rapid progression to liver cirrhosis in immunocompromised patients. HEV seroprevalence in patients with Schistosoma mansoni in Brazil is unknown. We evaluated the prevalence of past or present HEV infection in schistosomiasis patients in Recife, Pernambuco, Brazil. A total of 80 patients with Schistosoma mansoni were consecutively enrolled in a cross-sectional study. Serum samples were tested for the presence of anti-HEV IgG antibodies by enzyme immunoassay (Wan tai anti-HEV IgG, Beijing, China) and for the presence of HEV RNA using real time reverse transcriptase-polymerase chain reaction with primers targeting the HEV ORF2 and ORF3. Clinical and laboratory tests as well as abdominal ultrasound were performed at the same day of blood collection. Results: Anti-HEV IgG was positive in 18.8% (15/80) of patients with SM. None of the samples tested positive for anti-HEV IgM or HEV-RNA. Patients with anti-HEV IgG positive presented higher levels of alanine aminotranferase (p = 0.048) and gama-glutamil transferase (p = 0.022) when compared to patients without anti-HEV IgG antibodies. Conclusion: This study demonstrates that the seroprevalence of HEV is high in patients with Schistosoma mansoni in Northeastern of Brazil. Past HEV infection is associated with higher frequency of liver enzymes abnormalities. HEV infection and its role on the severity of liver disease should be further investigated among patients with Schistosoma mansoni. (C) 2016 Elsevier Editora Ltda.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo
dc.format.extent262-266
dc.language.isoeng
dc.publisherElsevier Brazil
dc.relation.ispartofBrazilian Journal Of Infectious Diseases
dc.rightsAcesso aberto
dc.subjectBrazilen
dc.subjectEpidemiologyen
dc.subjectHepatitis E virusen
dc.subjectSchistosomiasisen
dc.subjectSeroprevalenceen
dc.titleHepatitis E virus seroprevalence among schistosomiasis patients in Northeastern Brazilen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Div Infect Dis, Sao Paulo, SP, Brazil
dc.description.affiliationFleury SA Grp, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Div Gastroenterol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco UFPE, Div Gastroenterol, Recife, PE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Div Infect Dis, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Div Gastroenterol, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2012/22925-3
dc.description.sponsorshipIDFAPESP: 2013/03701-0
dc.identifier.fileS1413-86702016000300007.pdf
dc.identifier.scieloS1413-86702016000300007
dc.identifier.doi10.1016/j.bjid.2016.03.001
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000376443900007
dc.coverageRio De Janeiro
dc.citation.volume20
dc.citation.issue3


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