Genetic polymorphism of calcium-sensing receptor in women with breast cancer

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Campos-Verdes, Larysse Maira
Silva-Sampaio, Joao Paulo da
Costa-Silva, Danylo Rafhael
Oliveira, Victor Alves de
Conde Junior, Airton Mendes
Silva, Vladimir Costa
Alencar, Airlane Pereira
Campelo, Viriato
Lopes-Costa, Pedro Vitor
Gebrim, Luiz Henrique [UNIFESP]
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Breast cancer is a disease of unknown etiology, whose major risk factors are genetic alterations. Polymorphism of the calcium-sensing receptor (CaSR) has been a focus of some recent studies, due to a probable association with breast cancer risk and tumor aggressiveness. A relationship between polymorphic rs17251221 variant of the CaSR gene, and allele G (considered a gain-of-function mutation) and breast cancer risk has been stressed, despite the paucity of studies found in the literature. The present study involved 137 women (69 women with breast cancer-case
and 68 controls without breast cancer) who had 3 ml of peripheral blood drawn for DNA study. Genomic DNA was extracted from leukocytes by genotyping technique with real-time polymerase chain reaction. The AG genotype (rs17251221) was present in 13 women (18.84%) from the case group and in 8 (11.76%) women from the control group (p = 0.3434), while the GG genotype (rs17251221) did not occur in any group. In contrast, no statistically significant difference was observed between the AG genotype of variant rs17251221 in premenopausal case and control women (p = 0.71). There was also no statistically significant difference between postmenopausal case and control patients (p = 0.6851). In the current study, CaSR gene polymorphism of SNP variant rs17251221 did not show any statistically significant association with breast cancer, in both premenopausal and postmenopausal women.
Medical Oncology. Totowa, v. 35, n. 3, p. -, 2018.