Anti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smoke

Anti-inflammatory actions of herbal medicines in a model of chronic obstructive pulmonary disease induced by cigarette smoke

Author Possebon, Lucas Google Scholar
Lebron, Isabella de Souza Lima Google Scholar
Silva, Ligia Furlan da Google Scholar
Paletta, Julia Tagliaferri Google Scholar
Glad, Bruna Gabrieli Google Scholar
Sant'Ana, Monielle Autor UNIFESP Google Scholar
Iyomasa-Pilon, Melina Mizusaki Google Scholar
Souza, Helena Ribeiro Google Scholar
Costa, Sara de Souza Google Scholar
Rodriguesa, Giselda Pereira da Silva Google Scholar
Pereira, Maria de Lourdes Google Scholar
Moreno, Andreia de Haro Google Scholar
Girol, Ana Paula Google Scholar
Abstract The effects of four medicinal herbs (Arctium lappa, Plantago major, Mikania glomerata Spreng and Equisetum arvense) with anti-inflammatory properties were evaluated in a chronic obstructive pulmonary disease (COPD) model. Wistar rats were exposed to cigarette smoke during 8 weeks and one of the groups was orally given a solution containing 4% of each alcoholic herbal extracts during the exposure period. Control group was not exposed to smoke or treated. Histopathological, immunohistochemical and biochemical analyzes were performed. Normal blood plasma levels of gamma glutamyl transferase indicated no toxicity of the administered herbal extracts. The treatment reduced leukocytes influx in bronchoalveolar lavage, mast cell and macrophages numbers in lungs, as well as prevented pulmonary congestion and tracheal metaplasia. Herbal mixture also decreased plasma inflammatory mediator levels and pulmonary expression of annexin A1 and nuclear factor-k beta. Our data indicate synergistic and protective effects of the used herbal medicines in animals exposed to cigarette smoke as a potential therapeutic strategy.
Keywords COPD
Inflammatory mediators
xmlui.dri2xhtml.METS-1.0.item-coverage Issy-Les-Moulineaux
Language English
Sponsor Faculdades Integradas Padre Albino (FIPA), Catanduva, SP, Brazil
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), SP, Brazil
Grant number FAPESP: 2015/033595
Date 2018
Published in Biomedicine & Pharmacotherapy. Issy-Les-Moulineaux, v. 99, p. 591-597, 2018.
ISSN 0753-3322 (Sherpa/Romeo, impact factor)
Publisher Elsevier France-Editions Scientifiques Medicales Elsevier
Extent 591-597
Access rights Closed access
Type Article
Web of Science ID WOS:000427436800077

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