The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease
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Data
2018
Autores
Adegoke, Samuel Ademola [UNIFESP]
Braga, Josefina Aparecida Pellegrini [UNIFESP]
Adekile, Adekunle D.
Figueiredo, Maria Stella [UNIFESP]
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Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017
r=0.45, P=0.006, respectively)
inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008
r=-0.47, P=0.007
r=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis.
r=0.45, P=0.006, respectively)
inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008
r=-0.47, P=0.007
r=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis.
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Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 2, p. 159-162, 2018.