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dc.contributor.authorLobo, Thalita Frutuoso [UNIFESP]
dc.contributor.authorBorges, Cannila de Moraes [UNIFESP]
dc.contributor.authorMattar, Rosiane [UNIFESP]
dc.contributor.authorGomes, Caio Perez [UNIFESP]
dc.contributor.authorAngelo, Ana Geisa Santos de [UNIFESP]
dc.contributor.authorPendeloski, Karen Priscilla Tezotto [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.date.accessioned2020-07-20T16:31:20Z
dc.date.available2020-07-20T16:31:20Z
dc.date.issued2018
dc.identifierhttp://dx.doi.org/10.1111/aji.12810
dc.identifier.citationAmerican Journal Of Reproductive Immunology. Hoboken, v. 79, n. 3, p. -, 2018.
dc.identifier.issn1046-7408
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55885
dc.description.abstractProblem: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. Method of Study: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood. In addition, the expression of IL-10, TGF-B, and TNF-A in Treg and expression of IFN-G, TNF-A, granzyme, and perforin in NK cells were analyzed. Results: GDM patients had significantly lower frequency of TCD4(+)CD25(bright) and TCD4(+)CD25(+)FOXP3(high) cells, higher production of TNF-A by Treg cells and higher percentage of NKCD16(+)56(dim) cells than the controls. Conclusion: The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.format.extent-
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofAmerican Journal Of Reproductive Immunology
dc.rightsAcesso aberto
dc.subjectcytokineen
dc.subjectgestational diabetesen
dc.subjectnatural killer cellsen
dc.subjectoverweighten
dc.subjectregulatory T cellsen
dc.titleImpaired Treg and NK cells profile in overweight women with gestational diabetes mellitusen
dc.typeArtigo
dc.description.affiliationUniv Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2013/22754-7
dc.identifier.doi10.1111/aji.12810
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000425365100005
dc.coverageHoboken
dc.citation.volumev. 79
dc.citation.issue3


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