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dc.contributor.authorLobo, Thalita Frutuoso [UNIFESP]
dc.contributor.authorBorges, Cannila de Moraes [UNIFESP]
dc.contributor.authorMattar, Rosiane [UNIFESP]
dc.contributor.authorGomes, Caio Perez [UNIFESP]
dc.contributor.authorAngelo, Ana Geisa Santos de [UNIFESP]
dc.contributor.authorPendeloski, Karen Priscilla Tezotto [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.identifier.citationAmerican Journal Of Reproductive Immunology. Hoboken, v. 79, n. 3, p. -, 2018.
dc.description.abstractProblem: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. Method of Study: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood. In addition, the expression of IL-10, TGF-B, and TNF-A in Treg and expression of IFN-G, TNF-A, granzyme, and perforin in NK cells were analyzed. Results: GDM patients had significantly lower frequency of TCD4(+)CD25(bright) and TCD4(+)CD25(+)FOXP3(high) cells, higher production of TNF-A by Treg cells and higher percentage of NKCD16(+)56(dim) cells than the controls. Conclusion: The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.en
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.relation.ispartofAmerican Journal Of Reproductive Immunology
dc.rightsAcesso aberto
dc.subjectgestational diabetesen
dc.subjectnatural killer cellsen
dc.subjectregulatory T cellsen
dc.titleImpaired Treg and NK cells profile in overweight women with gestational diabetes mellitusen
dc.description.affiliationUniv Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Obstet, Sao Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2013/22754-7
dc.description.sourceWeb of Science
dc.citation.volumev. 79

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