Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus

Impaired Treg and NK cells profile in overweight women with gestational diabetes mellitus

Author Lobo, Thalita Frutuoso Autor UNIFESP Google Scholar
Borges, Cannila de Moraes Autor UNIFESP Google Scholar
Mattar, Rosiane Autor UNIFESP Google Scholar
Gomes, Caio Perez Autor UNIFESP Google Scholar
Angelo, Ana Geisa Santos de Autor UNIFESP Google Scholar
Pendeloski, Karen Priscilla Tezotto Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Abstract Problem: Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM. Method of Study: This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood. In addition, the expression of IL-10, TGF-B, and TNF-A in Treg and expression of IFN-G, TNF-A, granzyme, and perforin in NK cells were analyzed. Results: GDM patients had significantly lower frequency of TCD4(+)CD25(bright) and TCD4(+)CD25(+)FOXP3(high) cells, higher production of TNF-A by Treg cells and higher percentage of NKCD16(+)56(dim) cells than the controls. Conclusion: The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.
Keywords cytokine
gestational diabetes
natural killer cells
overweight
regulatory T cells
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number FAPESP: 2013/22754-7
Date 2018
Published in American Journal Of Reproductive Immunology. Hoboken, v. 79, n. 3, p. -, 2018.
ISSN 1046-7408 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Origin http://dx.doi.org/10.1111/aji.12810
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000425365100005
URI https://repositorio.unifesp.br/handle/11600/55885

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