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dc.contributor.authorVolobaev, Valentin P.
dc.contributor.authorLarionov, Aleksey V.
dc.contributor.authorKalyuzhnaya, Ekaterina E.
dc.contributor.authorSerdyukova, Ekaterina S.
dc.contributor.authorYakovleva, Svetlana
dc.contributor.authorDruzhinin, Vladimir G.
dc.contributor.authorBabich, Olga O.
dc.contributor.authorHill, Elena G.
dc.contributor.authorSemenihin, Victor A.
dc.contributor.authorPanev, Nikolay I.
dc.contributor.authorMinina, Varvara I.
dc.contributor.authorSivanesan, Saravana Devi
dc.contributor.authorNaoghare, Pravin
dc.contributor.authorSilva, Juliana da
dc.contributor.authorBarcelos, Gustavo Rafael Mazzaron [UNIFESP]
dc.contributor.authorProsekov, Alexander Y.
dc.identifier.citationMutagenesis. Oxford, v. 33, n. 2, p. 129-135, 2018.
dc.description.abstractAnthracosilicosis (AS), a prevalent form of pneumoconiosis among coal miners, results from the accumulation of carbon and silica in the lungs from inhaled coal dust. This study investigated genotoxic effects and certain cytokine genes polymorphic variants in Russian coal miners with.S. Peripheral leukocytes were sampled from 129 patients with AS confirmed by X-ray and tissue biopsy and from 164 asymptomatic coal miners. Four single-nucleotide polymorphisms were genotyped in the extracted DNA samples: IL1 beta T-511C (rs16944), IL6 C-174G (rs1800795), IL12b A1188C (rs3212227) and VEGFA C634G (rs2010963). Genotoxic effects were assessed by the analysis of chromosome aberrations in cultured peripheral lymphocytes. The mean frequency of chromatid-type aberrations and chromosome-type aberrations, namely, chromatid-type breaks and dicentric chromosomes, was found to be higher in AS patients [3.70 (95% confidence interval {CI}, 3.29-4.10) and 0.28 (95% CI, 0.17-0.38)] compared to the control group [2.41 (95% CI, 2.00-2.82) and 0.09 (95% CI, 0.03-0.15)], respectively. IL1 beta gene T/T genotype (rs16944) was associated with AS [17.83% in AS patients against 4.35% in healthy donors, odds ratio = 4.77 (1.88-12.15), P < 0.01]. A significant increase in the level of certain chromosome interchanges among AS donors is of interest because such effects are typical for radiation damage and caused by acute oxidative stress. IL1 beta T allele probably may be considered as an AS susceptibility factor among coal miners.en
dc.description.sponsorshipRussian Foundation for Basic Research
dc.publisherOxford Univ Press
dc.rightsAcesso restrito
dc.titleAssociations of polymorphisms in the cytokine genes IL1 beta (rs16944), IL6 (rs1800795), IL12b (rs3212227) and growth factor VEGFA (rs2010963) with anthracosilicosis in coal miners in Russia and related genotoxic effectsen
dc.description.affiliationKemerovo State Univ, Dept Genet, Soviet Ave 73, Kemerovo 650000, Russia
dc.description.affiliationKemerovo State Univ, Dept Bionanotechnol, Blvd Stroiteley 47, Kemerovo 650056, Russia
dc.description.affiliationKemerovo Reg Clin Hosp, Dept Occupat Pathol, Ave October 22, Kemerovo 650066, Russia
dc.description.affiliationReg Clin Ctr Miners Hlth, Dept Occupat Pathol, 7th Microdist 9, Kemerovo Region 652509, Russia
dc.description.affiliationRes Inst Complex Problems Hyg & Occupat Dis, St Kutuzova 23, Novokuznetsk 654041, Russia
dc.description.affiliationRussian Acad Sci, Siberian Branch, Fed Res Ctr Coal & Coal Chem, Soviet Ave 18, Kemerovo 650000, Russia
dc.description.affiliationNatl Environm Engn Res Inst, CSIR, Nagpur 440020, Maharashtra, India
dc.description.affiliationLutheran Univ Brazil ULBRA, Postgrad Program Mol & Cellular Biol Appl Hlth, Lab Genet Toxicol, BR-92425900 Canoas, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Hlth & Soc, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Hlth & Soc, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Sao Paulo, Brazil
dc.description.sponsorshipIDRFBR: 16-44-420926 r_a
dc.description.sponsorshipIDRFBR: 16-44-420087 r_a
dc.description.sponsorshipIDRFBR: 16-34-00441 mol_a
dc.description.sourceWeb of Science
dc.citation.volumev. 33

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