Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease

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dc.contributor.author Santos-Lobato, Bruno Lopes
dc.contributor.author Borges, Vanderci [UNIFESP]
dc.contributor.author Ferraz, Henrique Ballalai [UNIFESP]
dc.contributor.author Mata, Ignacio Fernandez
dc.contributor.author Zabetian, Cyrus P.
dc.contributor.author Tumas, Vitor
dc.date.accessioned 2020-07-20T16:31:13Z
dc.date.available 2020-07-20T16:31:13Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1016/j.niox.2017.06.004
dc.identifier.citation Nitric Oxide-Biology And Chemistry. San Diego, v. 74, p. 86-90, 2018.
dc.identifier.issn 1089-8603
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/55795
dc.description.abstract Background: Levodopa-induced dyskinesia (LID) is a common complication of advanced Parkinson's disease (PD). PD physiopathology is associated with dopaminergic and non-dopaminergic pathways, including the nitric oxide system. The present study aims to examine the association of a neuronal nitric oxide synthase gene (NOS1) single nucleotide polymorphism (rs2682826) with LID in PD patients. Methods and results: We studied 186 PD patients using levodopa. The presence of LID was defined as a MDS-UPDRS Part IV score >= 1 on item 4.1. We tested for association between NOS1 rs2682826 and the presence, daily frequency, and functional impact of LID using regression models, adjusting for important covariates. There was no significant association between genotype and any of the LID-related variables examined. Conclusions: Our results suggest that this NOS1 polymorphism does not contribute to LID susceptibility or severity. However, additional studies that include a comprehensive set of NOS1 variants will be needed to fully define the role of this gene in LID. (C) 2017 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Parkinson's Disease Foundation
dc.description.sponsorship International Parkinson and Movement Disorder Society
dc.format.extent 86-90
dc.language.iso eng
dc.publisher Academic Press Inc Elsevier Science
dc.relation.ispartof Nitric Oxide-Biology And Chemistry
dc.rights Acesso restrito
dc.subject Dyskinesia en
dc.subject Parkinson's disease en
dc.subject Levodopa en
dc.subject Nitric oxide en
dc.subject NOS1 gene en
dc.title Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease en
dc.type Artigo
dc.description.affiliation Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav Sci, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliation Univ Sao Paulo, Ctr Res Support Appl Neurosci NAPNA, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.description.affiliation Vet Affairs Puget Sound Hlth Care Syst, Seattle, WA USA
dc.description.affiliation Univ Washington, Dept Neurol, Seattle, WA 98195 USA
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.niox.2017.06.004
dc.description.source Web of Science
dc.identifier.wos WOS:000426538300011
dc.coverage San Diego
dc.citation.volume v. 74



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