Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD)

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dc.contributor.author Morandim-Giannetti, Andreia de Araujo
dc.contributor.author Rubio, Samantha Regina
dc.contributor.author Nogueira, Regina Freitas [UNIFESP]
dc.contributor.author Ortega, Fernando dos Santos
dc.contributor.author Magalhaes Junior, Octaviano [UNIFESP]
dc.contributor.author Schor, Paulo [UNIFESP]
dc.contributor.author Bersanetti, Patricia Alessandra [UNIFESP]
dc.date.accessioned 2020-07-20T16:30:56Z
dc.date.available 2020-07-20T16:30:56Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1002/jbm.b.33958
dc.identifier.citation Journal Of Biomedical Materials Research Part B-Applied Biomaterials. Hoboken, v. 106, n. 4, p. 1558-1566, 2018.
dc.identifier.issn 1552-4973
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/55596
dc.description.abstract Hydrogels are made from natural or synthetic polymers and, currently, they have many biomedical applications. In this work, the conditions for obtaining a hydrogel with similar physicochemical characteristics to the vitreous humor were defined using polyvinyl alcohol (PVA) and glutaraldehyde (GLUT) as cross-linker. The concentration of PVA and GLUT were modified, and their effect was analyzed in terms of the refractive index, density, and dynamic viscosity. The hydrogel which was obtained using 3.98% (w/V) of PVA, 3.13 mL (1.57 g) of GLUT in 100 mL, and the initial pH of 7.2 showed similar characteristics to the vitreous humor (density= 1.0174 +/- 0.0050 g mL(-1), dynamic viscosity=3.7425 +/- 0.1800 mPa s and refractive index=1.3410 +/- 0.0010). The hydrogels were further investigated by rheological measurements, infrared spectroscopy, differential scanning calorimetry, X-ray diffraction and determination of swelling degree. The reticulation with GLUT promoted an increase in viscosity and glass transition temperature. On the other hand, it stimulated a decrease in the swelling degree, crystallinity, melting temperature, and intensity of the band related to the -OH bond, compared with the PVA without reticulation. The reticulated hydrogel displayed Newtonian behavior and a higher apparent viscosity than the PVA. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1558-1566, 2018. en
dc.description.sponsorship Sao Paulo Research Foundation (FAPESP)
dc.description.sponsorship Centro Universitario FEI
dc.format.extent 1558-1566
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Journal Of Biomedical Materials Research Part B-Applied Biomaterials
dc.rights Acesso aberto
dc.subject design of experiments en
dc.subject glutaraldehyde en
dc.subject hydrogel en
dc.subject PVA en
dc.subject vitreous humor en
dc.title Characterization of PVA/glutaraldehyde hydrogels obtained using Central Composite Rotatable Design (CCRD) en
dc.type Artigo
dc.description.affiliation Ctr Univ FEI, Dept Engn Quim, Sao Bernardo Do Campo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliation Ctr Univ FEI, Dept Engn Mat, Sao Bernardo Do Campo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Oftalmol & Ciencias Visuais, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Bioquim, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2012/07343-8
dc.identifier.doi 10.1002/jbm.b.33958
dc.description.source Web of Science
dc.identifier.wos WOS:000430123100015
dc.coverage Hoboken
dc.citation.volume v. 106
dc.citation.issue 4



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