Genotype-guided warfarin therapy: current status

Genotype-guided warfarin therapy: current status

Author Tavares, Leticia C. Google Scholar
Marcatto, Leiliane R. Google Scholar
Santos, Paulo C. J. L. Autor UNIFESP Google Scholar
Abstract Warfarin pharmacogenomics has been an extensively studied field in the last decades as it is focused on personalized therapy to overcome the wide interpatient warfarin response variability and decrease the risk of side effects. In this expert review, besides briefly summarizing the current knowledge about warfarin pharmacogenetics, we also present an overview of recent studies that aimed to assess the efficacy, safety and economic issues related to genotype-based dosing algorithms used to guide warfarin therapy, including randomized and controlled clinical trials, meta-analyses and cost-effectiveness studies. To date, the findings still present disparities, mostly because of standard limitations. Thus, further studies should be encouraged to try to demonstrate the benefits of the application of warfarin pharmacogenomic dosing algorithms in clinical practice.
Keywords genotype-guided dosing algorithms
pharmacogenetic-based algorithm
pharmacogenetics
polymorphisms
vitamin k antagonist
warfarin
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Grant number FAPESP: 2013/09295-3
FAPESP: 2016/22507-8
FAPESP: 2016/23454-5
Date 2018
Published in Pharmacogenomics. London, v. 19, n. 7, p. 667-685, 2018.
ISSN 1462-2416 (Sherpa/Romeo, impact factor)
Publisher Future Medicine Ltd
Extent 667-685
Origin http://dx.doi.org/10.2217/pgs-2017-0207
Access rights Closed access
Type Revisão
Web of Science ID WOS:000432944400008
URI https://repositorio.unifesp.br/handle/11600/55548

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