Metilglioxal: uma toxina endógena?

Metilglioxal: uma toxina endógena?

Alternative title Is methylglyoxal an endogenous toxin?
Author Sartori, Adriano Google Scholar
Bechara, Etelvino José Henriques Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Methylglyoxal is a very reactive α-oxoaldehyde putatively produced by glycolysis, cytochrome P450-catalyzed acetone oxidation and aminoacetone oxidation. Methylglyoxal has been pointed as a substrate for the glyoxalase system ultimately energy-yielding pyruvate, but methylglyoxal is also a toxicant involved in protein aggregation and DNA modification. Controversial hypothesis on methylglyoxal as an anticancer agent, an energy-yielding glycolysis intermediates, and as a regulator of cell division have also been proposed. Methylglyoxal research focuses now on unveiling its biological properties and on the discovery of drugs capable to inhibit its toxic effects, principally in diabetes.
Keywords Keywords
methylglyoxal
glyoxalases
diabetes
Language Portuguese
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2010-01-01
Published in Química Nova. Sociedade Brasileira de Química, v. 33, n. 10, p. 2193-2201, 2010.
ISSN 0100-4042 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira de Química
Extent 2193-2201
Origin http://dx.doi.org/10.1590/S0100-40422010001000032
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000286298500032
SciELO ID S0100-40422010001000032 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/5552

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